REGIONAL DISTRIBUTION OF POTASSIUM, CALCIUM, AND 6 TRACE-ELEMENTS IN NORMAL HUMAN-BRAIN
REGIONAL DISTRIBUTION OF POTASSIUM, CALCIUM, AND 6 TRACE-ELEMENTS IN NORMAL HUMAN-BRAIN
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DOI：
10.1007/bf00965616
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发表时间：
1989-11-01
影响因子：
4.4
通讯作者：
DEREUCK, J
中科院分区：
文献类型：
--
作者：
DUFLOU, H;MAENHAUT, W;DEREUCK, J
采用粒子诱导x射线发射（PIXE）方法，对12个正常人大脑50个不同区域的K、Ca、Mn、Fe、Cu、Zn、Se、Rb等8种元素进行了测量。K、Fe、Cu、Zn、Se和Rb的干重浓度在灰质区始终高于白质区。混合成分区域的K、Zn、Se浓度介于灰质和白质之间，Rb浓度也在一定程度上介于两者之间，且随神经元密度的降低呈下降趋势。各脑区K、Ca、Zn、Se和Rb的平均干重浓度与各脑区的平均干湿比高度相关。然而，对于锰、铁和铜，没有观察到这种相关性，这些元素在基底神经节的几个结构中表现出升高的水平。K、Fe和Se的浓度似乎随年龄而变化。分层聚类分析表明，这些结构聚集成两大组，一组包括灰色和混合物质区域，另一组包括白色和混合物质区域。具有相同生理功能或形态相似区域的脑结构通常聚集在一个亚簇中。
Eight elements (i.e. K, Ca, Mn, Fe, Cu, Zn, Se, and Rb) were measured in 50 different regions of 12 normal human brains by particle-induced X-ray emission (PIXE) analysis. The dry weight concentrations of K, Fe, Cu, Zn, Se, and Rb were consistently higher for gray than for white matter areas. The K, Zn and Se concentrations for the regions of mixed composition and, to some extent, also the Rb concentrations, were intermediate between the gray and white matter values, and they tended to decrease with decreasing neuron density. The mean dry weight concentrations of K, Ca, Zn, Se, and Rb in the various brain regions were highly correlated with the mean wet-to-dry weight ratios of these regions. For Mn, Fe, and Cu, however, such a correlation was not observed, and these elements exhibited elevated levels in several structures of the basal ganglia. For K, Fe, and Se the concentrations seemed to change with age. A hierarchical cluster analysis indicated that the structures clustered into two large groups, one comprising gray and mixed matter regions, the other white and mixed matter areas. Brain structures involved in the same physiological function or morphologically similar regions often conglomerated in a single subcluster.