Combined analyses of gray matter voxel-based morphometry and white matter tract-based spatial statistics in pediatric bipolar mania
Combined analyses of gray matter voxel-based morphometry and white matter tract-based spatial statistics in pediatric bipolar mania
复制标题
小儿双相躁狂中基于灰质体素的形态测量和基于白质束的空间统计的联合分析
DOI：
10.1016/j.jad.2013.02.021
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发表时间：
2013-08-15
影响因子：
6.6
通讯作者：
Su, Linyan
中科院分区：
文献类型：
--
作者：
Gao, Weijia;Jiao, Qing;Su, Linyan
背景：大量证据表明双相情感障碍（BD）患者，包括儿童双相情感障碍（PBD），存在灰质（GM）和白质（WM）异常。然而，对 PBD 患者的情绪状态进行仔细分类的研究却很少。本研究的目的是调查PBD躁狂儿童和青少年的大脑结构变化。方法：本研究纳入18名10-18岁双相躁狂儿童和青少年（男/女，6/12）和18名年龄和性别匹配的健康对照。 3D T1 加权磁共振成像 (MRI) 和扩散张量成像 (DTI) 数据是在西门子 3.0 T 扫描仪上获得的。进行基于体素的形态测量（VBM）分析和基于束的空间统计（TBSS）分析来比较患者和对照组之间的灰质体积和白质各向异性分数（FA）值。进一步分析PBD患者各存活区域的MRI数据与临床特征的相关性。结果：与对照组相比，PBD躁狂症患儿左侧海马灰质体积减少。同时，在患者组的右前扣带回（AC）中检测到显着较低的 FA 值。在 PBD 狂热中没有观察到灰质体积或 FA 值增加的区域。当控制PBD躁狂症患者的临床特征时，海马体积与年轻躁狂评定量表（YMRS）评分呈负相关，然而，PBD躁狂症患者的存活区域的FA值与病程、发病年龄、发作次数或YMRS评分没有显着相关性。 局限性：目前的结果需要在更大样本中复制并在无药物治疗中验证 结论：我们的研究结果强调，PBD 躁狂症中存在广泛的脑结构病变（包括 GM 和 WM）。广泛发生的结构异常主要位于前边缘网络（ALN），这表明该网络可能导致 PBD 的情绪和认知失调。 (C) 2013 Elsevier B.V. 保留所有权利。
Background: Ample evidence has suggested the presence of gray matter (GM) and white matter (WM) abnormalities in bipolar disorder (BD) patients, including pediatric bipolar disorder (PBD). However, little research has been done in PBD patients that carefully classify the mood states. The aim of the present study is to investigate the brain structural changes in PBD-mania children and adolescents.Methods: Eighteen children and adolescents with bipolar mania (male/female, 6/12) aged 10-18 years old and 18 age- and sex-matched healthy controls were included in the present study. The 3D T1-weighted magnetic resonance imaging (MRI) and diffusion tensor imaging (DTI) data were obtained on a Siemens 3.0 T scanner. Voxel-based morphometry (VBM) analysis and tract-based spatial statistics (TBSS) analysis were conducted to compare the gray matter volume and white matter fractional anisotropy (FA) value between patients and controls. Correlations of the MRI data of each survived area with clinical characteristics in PBD patients were further analyzed.Results: As compared with the control group, PBD-mania children showed decreased gray matter volume in the left hippocampus. Meanwhile, significant lower FA value was detected in the right anterior cingulate (AC) in the patient group. No region of increased gray matter volume or FA value was observed in PBD-mania. The hippocampal volume was negatively associated with the Young Mania Rating Scale (YMRS) score when controlling for clinical characteristics in PBD-mania patients, however, there was no significant correlation of FA value of the survived area with illness duration, the onset age, number of episodes, or the YMRS score in PBD-mania patients.Limitation: The present outcomes require replication in larger samples and verification in medication free subjects.Conclusions: Our findings highlighted that extensive brain structural lesions (including GM and WM) were existed in PBD-mania. The widespread occurrence of structural abnormalities mainly located in the anterior limbic network (ALN) which suggested that this network might contribute to emotional and cognitive dysregulations in PBD. (C) 2013 Elsevier B.V. All rights reserved.