Decreased circulating Zinc levels in Parkinson's disease: a meta-analysis study.
Decreased circulating Zinc levels in Parkinson's disease: a meta-analysis study.
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帕金森病患者循环锌水平降低：一项荟萃分析研究
DOI：
10.1038/s41598-017-04252-0
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发表时间：
2017-06-20
影响因子：
4.6
通讯作者：
Wei MJ
中科院分区：
文献类型：
--
作者：
Du K;Liu MY;Zhong X;Wei MJ
关于锌 (Zn) 功能障碍与帕金森病 (PD) 的关系尚未达成共识。我们进行了一项荟萃分析，以评估 PD 患者血清、血浆和脑脊液 (CSF) 中的循环锌水平是否发生改变。通过检索PubMed和中国知网（CNKI）数据库，筛选出23篇已发表的研究。共有 803 名 PD 患者和 796 名对照者、342 名 PD 患者和 392 名对照者以及 135 名 PD 患者和 93 名对照者分别被纳入研究血清、血浆和脑脊液中的锌水平。我们的荟萃分析显示，与健康对照相比，PD患者的血清锌水平显着降低（SMD = −0.59；95% CI [−1.06，-0.12]；P = 0.014）。当同时分析血清和血浆研究时，发现 PD 患者的锌水平降低（SMD = −0.60，95% CI [−0.98；-0.22]；p = 0.002）。与健康对照组相比，PD患者的脑脊液锌水平有降低的趋势（SMD = −0.50；95% CI [−1.76, 0.76]；P = 0.439），但没有获得统计学意义，并且由于脑脊液研究样本量较小，该数据无法得出结论。这项研究表明，血清和血浆中锌水平降低与帕金森病风险增加相关。
There is no consensus on the involvement of zinc (Zn) dysfunctions in Parkinson’s Disease (PD). We performed a meta-analysis to evaluate whether circulating Zn levels in the serum, plasma, and cerebrospinal fluid (CSF) are altered in PD. Twenty-three published studies were selected by searching the databases of PubMed and China National Knowledge Infrastructure (CNKI). A total of 803 PD patients and 796 controls, 342 PD patients and 392 controls, and 135 PD patients and 93 controls were included to study Zn levels in the serum, plasma, and CSF, respectively. Our meta-analysis showed that the serum Zn levels were significantly lower in PD patients compared with health controls (SMD = −0.59; 95% CI [−1.06, −0.12]; P = 0.014). A reduced Zn levels in PD patients were found when serum and plasma studies were analyzed together (SMD = −0.60, 95% CI [−0.98; −0.22]; p = 0.002). PD patients had a tendency toward reduced CSF Zn levels compared with health controls (SMD = −0.50; 95% CI [−1.76, 0.76]; P = 0.439), but no statistical significance was obtained and this data did not allow conclusions due to a small sample size of CSF studies. This study suggests that reduced Zn levels in the serum and plasma are associated with an increased risk for PD.