Characterization of central nervous system structures by magnetic resonance diffusion anisotropy
Characterization of central nervous system structures by magnetic resonance diffusion anisotropy
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DOI：
10.1016/j.neuint.2003.11.014
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发表时间：
2004-09-01
影响因子：
4.2
通讯作者：
Maier, SE
中科院分区：
文献类型：
--
作者：
Mamata, H;Jolesz, FA;Maier, SE
扩散加权磁共振成像（MRI）提供有关组织水扩散的信息。可以用扩散张量MRI测量的扩散各向异性是由生物结构（例如神经纤维）引入的扩散限制的方向依赖性的定量测量。在脑、脑干和颈脊髓中获得扩散张量MRI数据。对于每个区域，在四名正常志愿者中进行扫描。在位于胼胝体、内囊、丘脑、尾状核、壳核、脑皮质、延髓锥体束、副橄榄核、背橄榄核、下橄榄核、脊髓白色和灰质的感兴趣区域内测量弥散各向异性指数（FA）。在胼胝体中测得的FA值最高（81 +/- 3%）。其他区域的值按以下顺序下降：延髓锥体束（72 +/- 1%），脊髓白色物质（65 +/- 4%），内囊（62 +/- 3%），副橄榄核（36 +/- 2%），脊髓灰质（34 +/- 5%），延髓背橄榄核（29 +/- 2%）、丘脑（28 +/- 2%）、下橄榄核（15 +/- 2%）、壳核（13 +/- 2%）、尾状核（13 +/- 2%）和大脑皮层（9 +/- 1%）。我们的研究结果表明，潜在的纤维结构，纤维密度和均匀性的神经纤维方向影响各向异性值的各种结构。具有扩散各向异性的各种中枢神经系统结构的表征是可能的，并且可能用于监测中枢神经系统中的退行性疾病。(C)2003爱思唯尔有限公司。保留所有权利。
Diffusion-weighted magnetic resonance imaging (MRI) provides information about tissue water diffusion. Diffusion anisotropy, which can be measured with diffusion tensor MRI, is a quantitative measure of the directional dependence of the diffusion restriction that is introduced by biological structures such as nerve fibers. Diffusion tensor MRI data was obtained in the brain, brain stein, and cervical spinal cord. For each region, scans were performed in four normal volunteers. Fractional anisotropy (FA), an index of diffusion anisotropy, was measured within regions of interest located in the corpus callosum, capsula interna, thalamus, caudate nucleus, putamen, brain cortex, pyramidal tract of the medulla, accessory olivary nucleus, dorsal olivary nucleus, inferior olivary nucleus, spinal white and gray matter. The highest FA value was measured in the corpus callosum (81 +/- 3%). The values of the other areas decreased in the following order: pyramidal tract in the medulla (72 +/- 1%), spinal white matter (65 +/- 4%), capsula interna (62 +/- 3%), accessory olivary nucleus (36 +/- 2%), spinal gray matter (34 +/- 5%), dorsal olivary nucleus in the medulla (29 +/- 2%), thalamus (28 +/- 2%), inferior olivary nucleus (15 +/- 2%), putamen (13 +/- 2%), caudate nucleus (13 +/- 2%), and brain cortex (9 +/- 1%). Our results indicate that the underlying fiber architecture, fiber density, and uniformity of nerve fiber direction affect anisotropy values of the various structures. Characterization of various central nervous system structures with diffusion anisotropy is possible and may be useful to monitor degenerative diseases in the central nervous system. (C) 2003 Elsevier Ltd. All rights reserved.