SYNTHESIS OF SELECTIVELY N-FUNCTIONALIZED POLYAMINE DERIVATIVES
SYNTHESIS OF SELECTIVELY N-FUNCTIONALIZED POLYAMINE DERIVATIVES
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DOI：
10.1002/hlca.19930760412
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发表时间：
1993-01-01
影响因子：
1.8
通讯作者：
HESSE, M
中科院分区：
文献类型：
--
作者：
FIEDLER, WJ;HESSE, M
以丙-1，3-二胺（1）为起始原料，经三步反应制得三胺亚精胺（2）的三重不同保护的衍生物8。保护的亚精胺衍生物8被转化成其精胺类似物12，一种有用的多胺中间体。以收敛的方式，通过偶联两个不同的和分别制备的丙烷-1，3-二胺单元15和17，得到四胺精胺（3）的四重不同保护的衍生物18。亚精胺衍生物19和精胺衍生物20，都选择性地保护在两个伯氨基，已分别从游离多胺2和3，在一个直接的方法。
A threefold differently protected derivative 8 of the triamine spermidine (2) has been prepared in three steps starting from propane-1,3-diamine (1). The protected spermidine derivative 8 was converted to its spermine analogue 12, a useful polyamine intermediate. In a convergent way, the fourfold differently protected derivative 18 of the tetraamine spermine (3) has been obtained by coupling the two different and separately prepared propane-1,3-diamine units 15 and 17. Spermidine derivative 19 and spermine derivative 20, both selectively protected at both primary amino groups, have been prepared from the free polyamines 2 and 3, respectively, in a direct approach.