Cellular networks involved in the influenza virus life cycle.
Cellular networks involved in the influenza virus life cycle.
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DOI：
10.1016/j.chom.2010.05.008
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发表时间：
2010-06-25
影响因子：
30.3
通讯作者：
Kawaoka Y
中科院分区：
文献类型：
--
作者：
Watanabe T;Watanabe S;Kawaoka Y
流感病毒引起流行病和大流行。像所有其他病毒一样，流感病毒依赖于宿主细胞机制来支持其生命周期。因此，参与病毒复制步骤的宿主功能的鉴定对于理解病毒生命周期的机制以及发现用于开发抗病毒化合物的新靶点具有极大的意义。多个实验室已经使用各种方法来探索参与流感病毒复制周期的宿主因素。其中一种最有效的方法是基于RNAi的全基因组筛选，它为寻找参与病毒复制的宿主因子提供了新的思路。在这篇综述中，我们研究了迄今为止在全基因组筛选中对流感病毒复制至关重要的细胞基因，评估了在这些研究中反复确定的途径，并讨论了这些途径如何参与流感病毒复制的各个步骤，最终导致对病毒生命周期的全面了解。
Influenza viruses cause epidemics and pandemics. Like all other viruses, influenza viruses rely on the host cellular machinery to support their life cycle. Accordingly, identification of host functions that participate in viral replication steps is of great interest to understand the mechanisms of the virus life cycle as well as to find new targets for the development of antiviral compounds. Multiple laboratories have used various approaches to explore host factors involvement in the influenza virus replication cycle. One of the most powerful approaches is an RNAi-based genome-wide screen, which has thrown new light on the search for host factors involved in virus replication. In this review, we examine the cellular genes identified to date as important for influenza virus replication in genome-wide screens, assess pathways that were repeatedly identified in these studies, and discuss how these pathways might be involved in the individual steps of influenza virus replication, ultimately leading to a comprehensive understanding of the virus life cycle.
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影响因子：
3
作者：
Bader, GD;Hogue, CW
通讯作者：
Hogue, CW
DOI：
10.1001/jama.295.8.joc60020
发表时间：
2006-02-22
影响因子：
120.7
作者：
Bright, RA;Shay, DK;Klimov, AI
通讯作者：
Klimov, AI
影响因子：
11.4
作者：
Akarsu, H;Burmeister, WP;Baudin, F
通讯作者：
Baudin, F
影响因子：
11.4
作者：
Chen, ZY;Li, YZ;Krug, RM
通讯作者：
Krug, RM
影响因子：
5.4
作者：
Ehrhardt, Christina;Wolff, Thorsten;Ludwig, Stephan
通讯作者：
Ludwig, Stephan