NEW POLYMERIC BIOCIDES - SYNTHESIS AND ANTIBACTERIAL ACTIVITIES OF POLYCATIONS WITH PENDANT BIGUANIDE GROUPS
NEW POLYMERIC BIOCIDES - SYNTHESIS AND ANTIBACTERIAL ACTIVITIES OF POLYCATIONS WITH PENDANT BIGUANIDE GROUPS
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DOI：
10.1128/aac.26.2.139
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发表时间：
1984-01-01
影响因子：
4.9
通讯作者：
TAZUKE, S
中科院分区：
文献类型：
--
作者：
IKEDA, T;YAMAGUCHI, H;TAZUKE, S
成功合成了带有双胍侧基的丙烯酸酯单体，并用丙烯酰胺制备了它们的均聚物和共聚物。这些聚合形式的阳离子消毒剂对革兰氏阳性菌表现出较高的抗菌活性，而对革兰氏阴性菌的活性较低。聚合物消毒剂的活性远高于单体物种的活性，并且根据聚合物和单体对致死作用的每个基本过程的贡献来讨论聚合物和单体之间的活性差异。 【供试微生物为枯草芽孢杆菌、金黄色葡萄球菌、大肠杆菌、产气杆菌、铜绿假单胞菌】。
Acrylate monomers with pendant biguanide groups were successfully synthesized and their homopolymers and copolymers were prepared with acrylamide. These cationic disinfectants of polymeric forms exhibited high antibacterial activity against gram-positive bacteria, whereas they were less active against gram-negative bacteria. The activity of the polymeric disinfectants was much higher than that of the monomeric species and the difference in activity between the polymers and monomers was discussed on the basis of their contributions to each elementary process of the lethal action. [The test organisms were Bacillus subtilis, Staphylococcus aureus, Escherichia coli, Aerobacter aerogenes and Pseudomonas aeruginosa.].