Development of organic dosimeters based on fluorescence of radiation reaction products of coumarin-3-carboxylicacid
Development of organic dosimeters based on fluorescence of radiation reaction products of coumarin-3-carboxylicacid
复制标题
基于香豆素-3-羧酸辐射反应产物荧光的有机剂量计的研制
DOI：
10.1007/s10854-021-07588-6
复制
发表时间：
2022
期刊：
影响因子：
--
通讯作者：
Keisuke Asai
中科院分区：
文献类型：
--
作者：
Ritsuha Tanaka;Masanori Koshimizu;Ichiro Kawamura;Yutaka Fujimoto;Keisuke Asai
我们开发了可以用作组织等效剂量计的有机材料。研究了一种水溶性香豆素衍生物香豆素-3-羧酸（C3CA）的辐射诱导反应。将C3CA添加到聚氯乙烯（PVC）、聚甲基丙烯酸甲酯（PMMA）和聚乙烯醇（PVA）中；测定了各含C3CA聚合物在x射线照射前后的光致发光光谱；根据荧光强度的变化来比较它们对x射线的敏感度。三种聚合物在x射线照射下，由C3CA产生荧光分子。基于PVC、PMMA和PVA的材料分别对高达400 Gy、8 kGy和1 kGy剂量的x射线敏感。这些结果表明辐照后聚合物产生的自由基被添加到香豆素中。此外，三氯乙酸的加入增强了pmma基样品的剂量敏感性。这些结果表明，C3CA的辐射诱导反应可以用作组织等效剂量计，而聚氯乙烯具有较高的剂量敏感性，是该材料的最佳聚合物。g值的差异和聚合物中产生的自由基的反应性导致了剂量敏感性的差异。
We developed organic materials that can be used as tissue-equivalent dosimeters. We focused on radiation-induced reactions of a water-soluble coumarin derivative, coumarin-3-carboxyl acid (C3CA). C3CA was added to polyvinyl chloride (PVC), polymethyl methacrylate (PMMA), and polyvinyl alcohol (PVA); the photoluminescence spectra of each polymer containing C3CA before and after X-ray irradiation were measured; their sensitivities to X-rays were compared based on changes in their fluorescence intensity. The fluorescent molecules were produced from C3CA upon X-ray irradiation of the three types of polymers. The materials based on PVC, PMMA, and PVA were sensitive to X-rays for doses up to 400 Gy, 8 kGy, and 1 kGy, respectively. These results suggest that the radicals produced from the polymers upon irradiation were added to coumarin. Furthermore, the addition of trichloroacetic acid enhanced the dose sensitivity of the PMMA-based samples. These results indicate that radiation-induced reactions of C3CA can be utilized as tissue-equivalent dosimeters and PVC is the best polymer for this material because of its high dose sensitivity. The difference in theGvalues and the reactivity of radicals produced in the polymers contributes to the difference in dose sensitivities.