Elevated protein-bound levels of the lipid peroxidation product, 4-hydroxy-2-nonenal, in brain from persons with mild cognitive impairment
Elevated protein-bound levels of the lipid peroxidation product, 4-hydroxy-2-nonenal, in brain from persons with mild cognitive impairment
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DOI：
10.1016/j.neulet.2005.12.017
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发表时间：
2006-04-24
影响因子：
2.5
通讯作者：
Sultana, R
中科院分区：
文献类型：
--
作者：
Butterfield, DA;Reed, T;Sultana, R
氧化损伤是许多与年龄相关的神经退行性疾病的特征，包括阿尔茨海默病（AD）。4-羟基-2-壬烯醛（HNE）是细胞膜中不饱和脂质（特别是花生四烯酸）自由基介导的脂质过氧化的高反应性产物。在本研究中，我们第一次表明，在短的死后间隔，HNE的水平升高，轻度认知障碍（MCI）海马和下顶叶小叶相比，控制大脑中获得的大脑。因此，MCI脑中HNE水平的增加暗示脂质过氧化是AD病理生理学的早期事件，也表明在MCI阶段或更早阶段预防脂质过氧化的药物干预可能是延迟或预防AD进展的有希望的治疗策略。(c)2005爱思唯尔爱尔兰有限公司保留所有权利。
Oxidative damage is a feature of many age-related neurodegenerative diseases, including Alzheimer's disease (AD). 4-Hydroxy-2-nonenal (HNE) is a highly reactive product of the free radical-mediated lipid peroxidation of unsaturated lipids, particularly arachidonic acid, in cellular membranes. In the present study we show for the first time in brain obtained at short postmortem intervals that the levels of HNE are elevated in mild cognitive impairment (MCI) hippocampus and inferior parietal lobules compared to those of control brain. Thus, increased levels of HNE in MCI brain implicate lipid peroxidation as an early event in AD pathophysiology and also suggest that the pharmacologic intervention to prevent lipid peroxidation at the MCI stage or earlier may be a promising therapeutic strategy to delay or prevent progression to AD. (c) 2005 Elsevier Ireland Ltd. All rights reserved.