Increasing Incidence of Intrahepatic Cholangiocarcinoma and its Relationship to Chronic Viral Hepatitis
Increasing Incidence of Intrahepatic Cholangiocarcinoma and its Relationship to Chronic Viral Hepatitis
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DOI：
10.6004/jnccn.2009.0030
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发表时间：
2009-04-01
影响因子：
13.4
通讯作者：
Yen, Yun
中科院分区：
文献类型：
--
作者：
Chang, Kwang-Yu;Chang, Jang-Yang;Yen, Yun
原发性肝癌是全球第六大常见癌症和第三大常见癌症死亡原因。胆管癌是仅次于肝细胞癌的第二常见原发性肝脏肿瘤。由于肝内胆管细胞癌的发病率在世界上大多数地区都在上升，因此迫切需要确定这一问题的主要原因。尽管肝内胆管细胞癌的危险因素众所周知，但最近的报道主要集中在慢性B型和C型肝炎病毒感染上，因为越来越多的研究观察到了相关性。然而，由于临床报道的多样性和缺乏体外证据，这种关系仍然不能确定。应强调这一问题，并需要进一步调查以澄清。（JNCCN 2009;7：423-427）
Primary liver cancer is the sixth most common cancer and third most common cause of cancer death worldwide. Cholangiocarcinoma is the second most common primary liver tumor after hepatocellular carcinoma. Because the incidence of intrahepatic cholangiocarcinoma is rising in most areas worldwide, identification of the main causes' of this problem is urgently needed. Despite well-known risk factors in the development of intrahepatic cholangiocarcinoma, recent reports focus on chronic hepatitis B and C viral infections because an increasing number of studies have observed an association. The relationship, however, is still not conclusive because of the diversity in clinical reports and the lack of in vitro evidences. This issue should be emphasized and further investigation is required for clarification. (JNCCN 2009;7:423-427)