The relationship between psychologic distress and cancer-related fatigue
The relationship between psychologic distress and cancer-related fatigue
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DOI：
10.1002/cncr.11463
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发表时间：
2003-07-01
期刊：
影响因子：
6.2
通讯作者：
Erder, MH
中科院分区：
文献类型：
--
作者：
Tchekmedyian, NS;Kallich, J;Erder, MH
背景作者研究了肺癌贫血患者的抑郁和焦虑水平变化与疲劳水平变化之间的关系，这些患者参加了一项随机、双盲、安慰剂对照的达贝泊汀α治疗贫血的临床试验。患者在试验期间完成了简明症状量表（BSI）抑郁和焦虑子量表以及癌症治疗功能评估（FACT）疲劳子量表。使用Pearson相关系数比较BSI评分的变化与FACT疲劳评分的变化。多元回归模型用于探索社会人口统计学和临床解释变量。基线时，250例患者中分别有25%和35%报告了高水平的焦虑和抑郁（标准BSI评分大于或等于65）。BSI焦虑和抑郁子量表标准化评分的变化与FACT疲劳评分变化的相关系数分别为-0.45（P < 0.001）和-0.44（P < 0.001）。在多元回归模型中，FACT疲劳评分的变化是唯一显著的解释变量（P < 0.001）。FACT疲劳评分每提高一个单位，焦虑和抑郁水平分别相应提高0.7分和0.8分。疲劳的改善与焦虑和抑郁的减少显著相关。对于贫血患者，达贝泊汀α治疗可改善或逆转疲劳。因此，疲劳程度较低的患者也可能受益于焦虑和抑郁水平的降低。Cancer 2003;98：198-203. (C)2003年美国癌症协会。
BACKGROUND. The authors examined the relationship between changes in depression and anxiety levels with changes in fatigue levels among anemic patients with lung cancer who participated in a randomized, double-blind, placebo-controlled clinical trial of darbepoetin alfa for the treatment of anemia.METHODS. Patients completed the Brief Symptom Inventory (BSI) Depression and Anxiety subscales and the Functional Assessment of Cancer Therapy (FACT) Fatigue subscale during the trial. Pearson correlation coefficients were used to compare changes in the BSI scores with changes in the FACT Fatigue scores. Multiple regression models were used to explore sociodemographic and clinical explanatory variables.RESULTS. At baseline, 25% and 35% of 250 patients reported high levels (normed BSI scores greater than or equal to 65) of anxiety and depression, respectively. Correlations of changes in normed BSI Anxiety and Depression subscale scores with changes in FACT Fatigue scores had coefficients of -0.45 (P < 0.001) and -0.44 (P < 0.001), respectively. In the multiple regression models, change in the FACT Fatigue score was the only significant explanatory variable (P < 0.001). For every unit improvement in FACT Fatigue score, there was a corresponding improvement of 0.7 points and 0.8 points in anxiety and depression levels, respectively.CONCLUSIONS. Improvements in fatigue were associated significantly with reductions in anxiety and depression. For patients with anemia, fatigue can be improved or reversed with darbepoetin alfa therapy. Thus, less fatigued patients also may benefit from reduced levels of anxiety and depression. Cancer 2003;98:198-203. (C) 2003 American Cancer Society.