Focally injected adenosine prevents seizures in the rat
Focally injected adenosine prevents seizures in the rat
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DOI：
10.1016/j.expneurol.2004.07.017
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发表时间：
2004-12-01
影响因子：
5.3
通讯作者：
Fisher, RS
中科院分区：
文献类型：
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作者：
Anschel, DJ;Ortega, EL;Fisher, RS
预防性药物直接注射到癫痫发作病灶上有可能改善癫痫发作控制，副作用比全身治疗少。使用剂量反应模型，我们评估了腺苷应用于12只大鼠局灶性癫痫发作预防的有效性。与对照组相比，腺苷治疗组的总棘波和脑电图发作事件显著减少（P
Prophylactic drug injection directly onto a seizure focus has the potential to improve seizure control with fewer side effects than is produced by systemic therapy. Using a dose-response model, we evaluated the effectiveness of adenosine application for focal seizure prophylaxis in 12 rats. Total spikes and electroencephalographic ictal events were reduced significantly by treatment with adenosine compared to control (P