VelB/VeA/LaeA complex coordinates light signal with fungal development and secondary metabolism
VelB/VeA/LaeA complex coordinates light signal with fungal development and secondary metabolism
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DOI：
10.1126/science.1155888
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发表时间：
2008-06-13
期刊：
影响因子：
56.9
通讯作者：
Braus, Gerhard H.
中科院分区：
文献类型：
--
作者：
Bayram, Oezguer;Krappmann, Sven;Braus, Gerhard H.
分化和次生代谢是真菌中对光有响应的相关过程。在构巢曲霉中，光抑制有性生殖以及次生代谢。我们鉴定出了异源三聚体绒毛复合物VelB/VeA/LaeA，它将对光有响应的发育调控与次生代谢的控制联系起来。主要在黑暗中表达的VeA与在有性发育过程中表达的VelB发生物理相互作用。VeA将VelB与次生代谢的核主调控因子LaeA连接起来。velB或veA的缺失都会导致有性子实体形成和次生代谢产物产生方面的缺陷。
Differentiation and secondary metabolism are correlated processes in fungi that respond to light. In Aspergillus nidulans, light inhibits sexual reproduction as well as secondary metabolism. We identified the heterotrimeric velvet complex VelB/VeA/LaeA connecting light-responding developmental regulation and control of secondary metabolism. VeA, which is primarily expressed in the dark, physically interacts with VelB, which is expressed during sexual development. VeA bridges VelB to the nuclear master regulator of secondary metabolism, LaeA. Deletion of either velB or veA results in defects in both sexual fruiting-body formation and the production of secondary metabolites.