Evidence for Pretreatment LICI Deficits Among Depressed Children and Adolescents With Nonresponse to Fluoxetine
Evidence for Pretreatment LICI Deficits Among Depressed Children and Adolescents With Nonresponse to Fluoxetine
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DOI：
10.1016/j.brs.2013.11.006
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发表时间：
2014-03-01
影响因子：
7.7
通讯作者：
Daskalakis, Zafiris J.
中科院分区：
文献类型：
--
作者：
Croarkin, Paul E.;Nakonezny, Paul A.;Daskalakis, Zafiris J.
背景：研究表明γ -氨基丁酸受体功能的改变在抑郁症中起作用。双脉冲经颅磁刺激（TMS）模式是对皮层抑制和兴奋回路的无创测量。目的/假设：本研究考察了氟西汀治疗的儿童和青少年重度抑郁症患者的预处理短间隔皮质内抑制（SICI）、长间隔皮质抑制（LICI）和皮质内促进（ICF）。主要目的是检查这些措施与后续治疗反应的关系。假设预处理GABA和谷氨酸介导的神经传递的改变与氟西汀无反应有关。
Background: Research suggests that alterations in gamma-aminobutyric acid receptor functioning have a role in depression. Paired-pulse transcranial magnetic stimulation (TMS) paradigms are noninvasive measures of cortical inhibitory and excitatory circuits.Objective/hypothesis: The present study examined pretreatment short-interval intracortical inhibition (SICI), long-interval cortical inhibition (LICI), and intracortical facilitation (ICF) in children and adolescents with major depressive disorder who were initiating fluoxetine treatment. The primary objective was to examine the relationship of these measures with subsequent treatment response. It was hypothesized that alterations in pretreatment GABA and glutamate mediated neurotransmission, would be associated with fluoxetine nonresponse.