Moderate alcohol consumption reduces plasma C-reactive protein and fibrinogen levels; a randomized, diet-controlled intervention study
Moderate alcohol consumption reduces plasma C-reactive protein and fibrinogen levels; a randomized, diet-controlled intervention study
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DOI：
10.1038/sj.ejcn.1601459
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发表时间：
2002-11-01
影响因子：
4.7
通讯作者：
Hendriks, HFJ
中科院分区：
文献类型：
--
作者：
Sierksma, A;van der Gaag, MS;Hendriks, HFJ
目的：评估适量饮酒对急性期蛋白 C 反应蛋白和纤维蛋白原的影响。设计：随机、饮食对照、交叉研究。背景：该研究在荷兰 Zeist 的 TNO 营养与食品研究中心进行。受试者：包括 10 名中年男性和 10 名绝经后女性，他们均表面健康、不吸烟且适度饮酒。一名女性因与治疗无关的原因而退出。其余19名受试者成功完成了实验。 干预措施：在连续两个为期三周的时间里，男性在晚餐时喝了四杯啤酒，女性在晚餐时喝了三杯啤酒或无酒精啤酒（对照）。在这 6 周内，向受试者提供的总饮食成分基本相同。每次治疗前有一个为期 I 周的清除期，以补偿可能的残留效应。结果：与不喝啤酒相比，饮用啤酒 3 周后，血浆 C 反应蛋白和纤维蛋白原水平分别降低 35%（P=0.02）和 12.4%（P < 0.001）。结论：适量饮酒显着降低血浆 C 反应蛋白和纤维蛋白原水平。酒精的抗炎作用可能有助于解释适量饮酒与降低心血管疾病风险之间的联系。赞助：荷兰酒精研究基金会 (SAR)。
Objective: To evaluate the effect of moderate alcohol consumption on the acute phase proteins C-reactive protein and fibrinogen.Design: Randomized, diet-controlled, cross-over study.Setting: The study was performed at TNO Nutrition and Food Research, Zeist, The Netherlands.Subjects: Ten middle-aged men and 10 postmenopausal women, all apparently healthy, non-smoking and moderate alcohol drinkers, were included. One women dropped out because of a treatment-unrelated cause. The remaining 19 subjects finished the experiment successfully.Interventions: Men consumed four glasses and women consumed three glasses of beer or no-alcohol beer (control) with evening dinner during two successive periods of 3 weeks. The total diet was supplied to the subjects and had essentially the same composition during these 6 weeks. Before each treatment there was a I week washout period to compensate for possible carry-over effects.Results: Plasma C-reactive protein and fibrinogen levels were decreased by 35% (P=0.02) and 12.4% (P < 0.001), respectively, after 3 weeks' consumption of beer, as compared to no-alcohol beer consumption.Conclusions: Moderate alcohol consumption significantly decreased plasma C-reactive protein and fibrinogen levels. An anti-inflammatory action of alcohol may help explain the link between moderate alcohol consumption and lower cardiovascular disease risk.Sponsorship: Dutch Foundation for Alcohol Research (SAR).