Obesity and sex steroid changes across puberty: Evidence for marked hyperandrogenemia in pre- and early pubertal obese girls
Obesity and sex steroid changes across puberty: Evidence for marked hyperandrogenemia in pre- and early pubertal obese girls
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DOI：
10.1210/jc.2006-2002
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发表时间：
2007-02-01
影响因子：
5.8
通讯作者：
Marshall, John C.
中科院分区：
文献类型：
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作者：
McCartney, Christopher R.;Blank, Susan K.;Marshall, John C.
背景：青春期周围肥胖与性类固醇浓度异常有关，但这些异常的发生时间和程度尚不清楚。目的：本研究的目的是评估肥胖女孩青春期高雄激素血症的程度，并评估坦纳1-3期女孩一夜之间的性类固醇变化。设计：这是一个横断面分析。环境：本研究在普通临床研究中心进行。研究对象：30例正常体重（年龄体重指数< 85%）和74例肥胖（年龄体重指数>= 95%）的青春期少女。干预：空腹时采集血样（约0500-0700小时）。从23名Tanner 1-3女孩中获得了前一天晚上（大约2300小时）的样本。主要观察指标：测量按坦纳分期分层的激素浓度。结果：与正常体重女孩相比，肥胖女孩青春期平均游离睾酮(T)升高2- 9倍，而肥胖Tanner 1-3女孩的空腹胰岛素升高3倍（P < 0.05）。肥胖Tanner 1和Tanner 2女孩的LH平均值较低（P < 0.05），而较成熟女孩的LH平均值较低（P < 0.05）。在体重正常的Tanner 1-3女孩亚组（n = 17）中，平均孕酮(P)和T在一夜之间分别增加2.3倍和2.4倍(P
Context: Peripubertal obesity is associated with abnormal sex steroid concentrations, but the timing of onset and degree of these abnormalities remain unclear.Objective: The objective of the study was to assess the degree of hyperandrogenemia across puberty in obese girls and assess overnight sex steroid changes in Tanner stage 1-3 girls.Design: This was a cross-sectional analysis.Setting: The study was conducted at general clinical research centers.Subjects: Thirty normal-weight (body mass index for age < 85%) and 74 obese (body mass index for age >= 95%) peripubertal girls. Intervention: Blood samples (circa 0500-0700 h) were taken while fasting. Samples from the preceding evening (circa 2300 h) were obtained in 23 Tanner 1-3 girls.Main Outcome Measures: Hormone concentrations stratified by Tanner stage were measured.Results: Compared with normal-weight girls, mean free testosterone (T) was elevated 2- to 9-fold across puberty in obese girls, whereas fasting insulin was 3-fold elevated in obese Tanner 1-3 girls (P < 0.05). Mean LH was lower in obese Tanner 1 and 2 girls (P < 0.05) but not in more mature girls. In a subgroup of normal-weight Tanner 1-3 girls (n = 17), mean progesterone (P) and T increased overnight 2.3- and 2.4-fold, respectively (P