Synthesis and in vitro antitumor activity of novel 2-alkyl-5-methoxycarbonyl-11- methyl-6H-pyrido[4,3-b]carbazol-2-ium and 2-alkylellipticin-2-ium chloride derivatives
Synthesis and in vitro antitumor activity of novel 2-alkyl-5-methoxycarbonyl-11- methyl-6H-pyrido[4,3-b]carbazol-2-ium and 2-alkylellipticin-2-ium chloride derivatives
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新型2-烷基-5-甲氧基羰基-11-甲基-6H-吡啶并[4,3-b]咔唑-2-鎓和2-烷基玫瑰树碱-2-鎓氯化物衍生物的合成及其体外抗肿瘤活性
DOI：
10.1016/j.ejmech.2014.05.032
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发表时间：
2014
期刊：
影响因子：
--
通讯作者：
Takeo Konakahara
中科院分区：
文献类型：
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作者：
Ryota Mori;Asako Kato;Kousuke Komenoi;Haruaki Kurasaki;Touru Iijima;Masashi Kawagoshi;Y. B. Kiran;Shoichi Takeda;Norio Sakai;Takeo Konakahara
合成了21种2位含氧二亚乙基亚硝脲的椭圆藤碱衍生物和5-甲氧羰基-11-甲基-6H-吡啶并[4，3-B]咔唑类化合物，并评价了它们对HeLa S-3细胞的细胞毒性。其中一些新化合物具有较强的抗肿瘤活性。
Twenty-one types of novel ellipticine derivatives and pyridocarbazoles (5-methoxycarbonyl-11-methyl-6H-pyrido[4,3-b]carbazoles) with a nitrosourea moiety, linked by an oxydiethylene unit at the 2 position, were synthesized, and their cytotoxicity against HeLa S-3 cells was evaluated. Some of these new compounds exhibited potent antitumor activity by comparison with that of ellipticine.