Lung recoil and the determination of airflow limitation in cystic fibrosis and asthma
Lung recoil and the determination of airflow limitation in cystic fibrosis and asthma
复制标题
囊性纤维化和哮喘中的肺反冲和气流受限的测定
DOI：
10.1002/ppul.1950150103
复制
发表时间：
1993
影响因子：
3.1
通讯作者：
A. Coates
中科院分区：
文献类型：
--
作者：
A. Zapletal;K. Desmond;D. Demizio;A. Coates
肺回缩压的降低可能会加重囊性纤维化（CF）或哮喘患者可能存在的任何气流限制。在一组22名8-24岁的儿童和年轻人（8例囊性纤维化，8例无症状哮喘，6例健康对照）中，使用食管球囊测量100%，90%和60% TLC时的肺反冲压（Pst）和静态肺顺应性（Cst）。测定25%VC时最大呼气流量（Vmax 25，）、1秒用力呼气量（FEV 1，）和比气道传导率（sGaw）。在所有患者中，Vmax 25降低，CF患者的气道阻塞更明显。肺纤维化和哮喘患者的Pst降低，肺纤维化患者的Pst降低更多。两组的Cst均正常，因为压力-容积曲线向上和向左移动。Pst在60%、90%时呈显著正相关。TLC、Vmax 25和FEV 1均为100%（P < 0.01）。sGaw与Pst 90和Pst 60相关（r分别为0.47和0.53; P均< 0.05）。在任何肺容量下，Cst和Pst之间均无相关性。Cst与Vmax 25、FEV 1或sGaw之间未观察到相关性。这些结果表明，弹性肺回缩压力的损失是一个因素，在儿童和年轻的成人与CF或哮喘气流限制。© 1993 Wiley利斯公司
A reduction of lung recoil pressure could aggravate any air flow limitation that might be present in patients with cystic fibrosis (CF) or asthma. In a group of 22 children and young adults (8 with cystic fibrosis, 8 with asymptomatic asthma, and 6 healthy controls) aged 8–24 years, lung recoil pressure (Pst) at l00%, 90%, and 60% of TLC and static lung compliance (Cst) were measured using an esophageal balloon. The indices of airflow limitation, including maximal expiratory flow at 25% VC (Vmax25,), forced expiratory volume in 1 second (FEV1,), and specific airway conductance (sGaw), were also measured. In all patients, Vmax25 was reduced, the airway obstruction being more pronounced in patients with CF. Pst was reduced in CF and asthma, again more in the patients with CF. Cst was normal in both groups because the pressure volume curve was shifted up and to the left. There were significant correlations between Pst at 60%, 90%. and 100% of TLC and both Vmax25 and FEV1, (P < 0.01). sGaw correlated with Pst90 and Pst6O (r = 0.47 and 0.53, respectively; P < 0.05 for both). No correlation was found between Cst and Pst at any lung volume. No correlations were observed between Cst and Vmax25, FEV1, or sGaw. These results suggest that loss of elastic lung recoil pressure is a factor in airflow limitation of children and young adults with CF or asthma. © 1993 Wiley‐Liss, Inc.