Nfil3 is required for the development of all innate lymphoid cell subsets.
Nfil3 is required for the development of all innate lymphoid cell subsets.
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DOI：
10.1084/jem.20140145
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发表时间：
2014-08-25
期刊：
影响因子：
--
通讯作者：
Carotta S
中科院分区：
文献类型：
--
作者：
Seillet C;Rankin LC;Groom JR;Mielke LA;Tellier J;Chopin M;Huntington ND;Belz GT;Carotta S
Nfil 3的缺失选择性地减少派伊尔斑形成，损害淋巴细胞的募集和分布，并损害对炎症和感染因子的免疫应答。先天性淋巴样细胞（ILC）群体保护免受感染，并且对于淋巴组织形成和损伤后的组织重塑至关重要。Nfil 3参与适应性免疫谱系和NK细胞发育的功能，但尚不清楚Nfil 3是否调节其他先天淋巴谱系。在这里，我们确定Nfil 3是必不可少的发展派尔集合淋巴结和ILC 2和ILC 3子集。Nfil 3的损失选择性地减少派尔集合淋巴结的形成，并伴随着受损的募集和分布的淋巴细胞内的补丁。ILC亚群表现出高Nfil 3表达，并且Nfil 3的遗传缺失严重损害了所有亚群的发育。随后，Nfil 3 −/−小鼠在受到炎症或感染因子攻击时对疾病高度易感。因此，我们证明Nfil 3是肺和肠道中免疫保护所必需的ILC亚群的发展的关键调节因子。
Loss of Nfil3 selectively reduces Peyer’s patch formation, impairing recruitment and distribution of lymphocytes and compromising immune responses to inflammatory and infectious agents. Innate lymphoid cell (ILC) populations protect against infection and are essential for lymphoid tissue formation and tissue remodeling after damage. Nfil3 is implicated in the function of adaptive immune lineages and NK cell development, but it is not yet known if Nfil3 regulates other innate lymphoid lineages. Here, we identify that Nfil3 is essential for the development of Peyer’s patches and ILC2 and ILC3 subsets. Loss of Nfil3 selectively reduced Peyer’s patch formation and was accompanied by impaired recruitment and distribution of lymphocytes within the patches. ILC subsets exhibited high Nfil3 expression and genetic deletion of Nfil3 severely compromised the development of all subsets. Subsequently, Nfil3−/− mice were highly susceptible to disease when challenged with inflammatory or infectious agents. Thus, we demonstrate that Nfil3 is a key regulator of the development of ILC subsets essential for immune protection in the lung and gut.
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影响因子：
20.3
作者：
Seillet, Cyril;Jackson, Jacob T.;Belz, Gabrielle T.
通讯作者：
Belz, Gabrielle T.
影响因子：
30.5
作者：
通讯作者：
--
DOI：
10.1073/pnas.94.6.2609
发表时间：
1997-03-18
影响因子：
11.1
作者：
Ikushima, S;Inukai, T;Look, AT
通讯作者：
Look, AT
DOI：
10.1084/jem.20130417
发表时间：
2013-12-16
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
Firth MA;Madera S;Beaulieu AM;Gasteiger G;Castillo EF;Schluns KS;Kubo M;Rothman PB;Vivier E;Sun JC
通讯作者：
Sun JC
影响因子：
4.4
作者：
Seillet, Cyril;Huntington, Nicholas D.;Carotta, Sebastian
通讯作者：
Carotta, Sebastian