INVOLVEMENT OF THE PINEAL-GLAND AND MELATONIN IN MURINE ANALGESIA
INVOLVEMENT OF THE PINEAL-GLAND AND MELATONIN IN MURINE ANALGESIA
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DOI：
10.1016/0024-3205(81)90710-4
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发表时间：
1981-01-01
期刊：
影响因子：
6.1
通讯作者：
WINTERS, WD
中科院分区：
文献类型：
--
作者：
LAKIN, ML;MILLER, CH;WINTERS, WD
显然，在小鼠中观察到的对吗啡的夜间敏感性增加的表达需要完整的松果体。松果体切除小鼠吗啡镇痛的昼夜节律不明显。用褪黑激素处理的小鼠表现出剂量相关的镇痛反应。在褪黑激素给药后给予阿片拮抗剂纳洛酮的动物中，未观察到疼痛敏感性降低。来自环境照明的信息通过松果体激素褪黑激素调节对疼痛的敏感性，褪黑激素被释放并作用于中枢神经系统的其他区域。
Apparently, an intact pineal gland is required for the expression of the increased nocturnal sensitivity to morphine observed in mice. The day/night rhythm of morphine analgesia was not evident in pinealectomized mice. Mice treated with melatonin exhibited a dose-related analgesic response. The decrease in sensitivity to pain was not observed in animals in which melatonin administration was followed by the opiate antagonist, naloxone. Information derived from environmental lighting regulates sensitivity to pain via the pineal gland hormone melatonin, which is released and acts upon other areas of the CNS.