EFFECTS OF PRENATAL EXPOSURE TO ETHANOL ON THE MATURATION OF THE PYRAMIDAL NEURONS IN THE CEREBRAL-CORTEX OF THE GUINEA-PIG - A QUANTITATIVE GOLGI-STUDY
EFFECTS OF PRENATAL EXPOSURE TO ETHANOL ON THE MATURATION OF THE PYRAMIDAL NEURONS IN THE CEREBRAL-CORTEX OF THE GUINEA-PIG - A QUANTITATIVE GOLGI-STUDY
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DOI：
10.1111/j.1365-2990.1985.tb00026.x
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发表时间：
1985-01-01
影响因子：
5
通讯作者：
GINER, P
中科院分区：
文献类型：
--
作者：
FABREGUES, I;FERRER, I;GINER, P
在新生豚鼠的体感大脑皮层中定量研究了妊娠期间慢性乙醇消耗对第五层锥体细胞发育的影响。将经过快速高尔基体方法处理的神经元的基底树突分枝的扩散和顶树突上的树突棘计数与接受不含酒精的等热量饮食的年龄匹配对照中发现的结果进行比较。在暴露于酒精的动物和对照动物之间，初级基底树突的数量(P<0.05)和距体体25μm处的树突分支(P<0.01)存在显着差异。顶端树突上的树突棘数量也存在显着差异（P < 0.001）。该实验模型进一步说明了产前乙醇暴露后大脑皮层的发育异常。
The effects of chronic ethanol consumption during gestation on the development of layer V pyramidal cells was studied quantitatively in the somatosensory cerebral cortex of newborn guinea-pig. The spread of the basilar dendritic arborizations and counts of dendritic spines on the apical dendrite of neurons that have been processed with the rapid Golgi method were compared with those found in age-matched controls receiving an isocaloric diet without alcohol. There were significant differences in the number of primary basilar dendrites (P < 0.05) and dendritic ramifications at a distance of 25 .mu.m from the soma (P < 0.01) between the alcohol-exposed and control animals. There also were significant differences in the number of dendritic spines on the apical dendrite (P < 0.001). This experimental model further illustrates developmental anomalies in the cerebral cortex following prenatal ethanol exposure.