The quantitative determination of R- and S-salsolinol in the striatum and adrenal gland of rats selectively bred for disparate alcohol drinking
The quantitative determination of R- and S-salsolinol in the striatum and adrenal gland of rats selectively bred for disparate alcohol drinking
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DOI：
10.1080/13556219971687
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发表时间：
1999-04-01
影响因子：
3.4
通讯作者：
Li, TK
中科院分区：
文献类型：
--
作者：
Haber, H;Dumaual, N;Li, TK
为探讨内源性1-甲基-6，7-二羟基-1，2，3，4-四氢异喹啉（salsolinol）在酒精中毒病因学中的双重作用，测定了选择性饲养的不同饮酒大鼠纹状体和肾上腺中salsolinol的浓度。与非酒精偏好（NP）和低酒精饮用（LAD）大鼠相比，酒精初始酒精偏好（P）和高酒精饮用（HAD）大鼠的纹状体和肾上腺猪毛菜醇含量显着降低。在大鼠的P-lille，4周的自由选择饮酒对纹状体的salsolinol水平没有显着影响，虽然肾上腺的salsolinol水平显着较高：在所有大鼠的纹状体中检测的salsolinol作为对映体的外消旋混合物发生，在4周的酒精爆炸后没有变化。与纹状体组织不同，酒精幼稚的P-大鼠的肾上腺含有显着更多的S-比R-猪毛菜醇（S/R = 83/17）和酒精消费导致形成的对映体的近外消旋混合物。这些结果表明，遗传因素在形成内源性猪毛菜醇和短期酒精摄入量的潜在调节的作用。
To explore the hypothesis that endogenous 1-methyl-6, 7-dihydroxy-1,2,3,4-tetrahydroisoquinoline (salsolinol) might be bivalved in the etiology of alcoholism, its concentration was determined in the striatum and adrenal gland of rats bred selectively for disparate alcohol drinking. The alcohol-naive alcohol-preferring (P) and the high-alcohol-drinking (HAD) lines of rats demonstrated significantly lower striatal and adrenal salsolinol content when compared with the alcohol-non-preferring (NP) and the low-alcohol-drinking (LAD) lines. In the P-lille of rats, 4 weeks of free-choice alcohol drinking had no significant effect on striatal salsolinol levels, although adrenal levels of salsolinol were significantly higher: The salsolinol assayed in the striatum of all lines of rats occurred as a racemic mixture of enantiomers that was unchanged following 4 weeks of alcohol explosive. Unlike striatal tissue, the adrenals of alcohol naive P-rats contained significantly More S- than R-salsolinol (ratio S/R = 83/17) and alcohol consumption resulted in the formation of a nearly racemic mixture of enantiomers. These results suggest a role for genetic factors in the formation of endogenous salsolinol and its potential regulation by short-term alcohol intake.