The interplay of transcriptional and post-transcriptional regulation of migration of mesenchymal stem cells during early stages of bone fracture healing
The interplay of transcriptional and post-transcriptional regulation of migration of mesenchymal stem cells during early stages of bone fracture healing
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DOI：
10.26355/eurrev_201712_13990
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发表时间：
2017-12-01
影响因子：
3.3
通讯作者：
Zhen, P.
中科院分区：
文献类型：
--
作者：
Dong, C. -H.;Deng, Y. -S.;Zhen, P.
骨折是一种医学状况，骨骼的连续性因跌倒或意外而断裂。骨折也可能是骨质疏松症、骨癌或成骨不完善等医疗条件造成的。在骨折愈合过程中，间充质干细胞(未分化的结缔组织细胞)从局部和全身来源招募。调控间充质细胞向骨折部位的迁移是理想的目标。尽管如此，仍有许多过程需要研究和分析。我们的目标是综合和审查关于这一专题的现有信息。
Bone fractures are a medical condition where the continuity of the bone is broken due to a fall or accident. The fracture may also be the result of medical conditions such as osteoporosis, cancers of bone or osteogenesis imperfect. During the bone fracture healing process, the mesenchymal stem cells (undifferentiated connective tissue cells) are recruited from local and systemic sources. The modulation of mesenchymal cell migration to the fractured site is the desired goal. Still, there are many processes that are still required to be studied and analyzed. We aimed to consolidate and review the available information on this topic.