Mannitol metabolism during pathogenic fungal-host interactions under stressed conditions.
Mannitol metabolism during pathogenic fungal-host interactions under stressed conditions.
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DOI：
10.3389/fmicb.2015.01019
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发表时间：
2015
影响因子：
5.2
通讯作者：
Upadhyay RS
中科院分区：
文献类型：
--
作者：
Meena M;Prasad V;Zehra A;Gupta VK;Upadhyay RS
许多植物和真菌产生甘露醇，甘露醇可以作为渗透调节剂或代谢库；此外，甘露醇还可以作为一种有效的活性氧(ROS)猝灭剂。一些植物病原真菌使用甘露醇来抑制ROS介导的植物抗性。甘露醇在植物和动物产生的细胞增强平衡中起着至关重要的作用。甘露醇同样作为减少能量、管理辅酶和控制细胞质pH值的来源，作为质子的汇或热点。在丝状真菌中，通过直接将6-磷酸果糖还原为甘露醇-1-磷酸，包括甘露醇-1-磷酸磷酸酶催化剂，研究了甘露醇生物合成和分解代谢的代谢途径。在植物中，甘露醇从甘露糖-6-磷酸整合为甘露醇-1-磷酸，然后甘露醇-1-磷酸脱磷为甘露醇。甘露醇脱氢酶在宿主-病原菌相互作用中起关键作用，必须与病原菌分泌的甘露醇共定位才能抵抗感染。
Numerous plants and fungi produce mannitol, which may serve as an osmolyte or metabolic store; furthermore, mannitol also acts as a powerful quencher of reactive oxygen species (ROS). Some phytopathogenic fungi use mannitol to stifle ROS-mediated plant resistance. Mannitol is essential in pathogenesis to balance cell reinforcements produced by both plants and animals. Mannitol likewise serves as a source of reducing power, managing coenzymes, and controlling cytoplasmic pH by going about as a sink or hotspot for protons. The metabolic pathways for mannitol biosynthesis and catabolism have been characterized in filamentous fungi by direct diminishment of fructose-6-phosphate into mannitol-1-phosphate including a mannitol-1-phosphate phosphatase catalyst. In plants mannitol is integrated from mannose-6-phosphate to mannitol-1-phosphate, which then dephosphorylates to mannitol. The enzyme mannitol dehydrogenase plays a key role in host–pathogen interactions and must be co-localized with pathogen-secreted mannitol to resist the infection.