MORTALITY OF WORKERS EXPOSED TO POLYCHLORINATED-BIPHENYLS - AN UPDATE
MORTALITY OF WORKERS EXPOSED TO POLYCHLORINATED-BIPHENYLS - AN UPDATE
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DOI：
10.1080/00039896.1987.9934355
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发表时间：
1987-11-01
期刊：
影响因子：
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通讯作者：
BROWN, DP
中科院分区：
文献类型：
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作者：
BROWN, DP
1981年报道了两家制造电容器的工厂中接触多氯联苯(PCB)的工人的回顾性队列死亡率研究。这项研究主要是为了研究与接触多氯联苯相关的癌症死亡风险。根据动物数据，肝癌是最令人感兴趣的疾病。由于死亡人数较少，观察期相对较短，这项研究被认为没有定论。这项研究已经更新，增加了7年的观察。研究队列中的死亡人数从163人增加到295人。发现所有原因的死亡率低于预期(295例观察死亡比318例预期死亡)以及所有癌症的死亡率(62例观察死亡比80例预期死亡)。在包括肝癌(原发和未指明的)、胆囊癌和胆道癌的疾病类别中，观察到的死亡人数显著高于预期的1.9人(观察到5人，预期为1.9人；p<；0.05)。在一家工厂受雇的女性身上观察到了大部分的过量。由于死亡人数很少，而且这一类别中的具体死因多种多样，因此仍然很难解释关于多氯联苯暴露的这些调查结果。
A retrospective cohort mortality study of workers exposed to polychlorinated biphenyls (PCBs) in two plants manufacturing electrical capacitors was reported in 1981. The study was conducted primarily to examine the risk of cancer mortality associated with exposure to PCBs. Based on animal data, liver cancer was the disease of most interest. Due to the small number of deaths and a relatively short observation period, the study was considered inconclusive. This study has been updated by adding 7 yr of observation. The number of deaths in the study cohort has increased from 163 to 295. Mortality from all causes was found to be lower than expected (295 observed vs. 318 expected deaths) as well as mortality from all cancers (62 observed vs. 80 expected deaths). A statistically significant excess in deaths was observed in the disease category that includes cancer of the liver (primary and unspecified), gall bladder, and biliary tract (5 observed vs. 1.9 expected; p < .05). Most of this excess was observed in women employed in one plant. Due to the small number of deaths and the variability of specific cause of death within this category, it remains difficult to interpret these findings in regard to PCB exposure.