Effect of Brown Seaweed Lipids on Fatty Acid Composition and Lipid Hydroperoxide Levels of Mouse Liver
Effect of Brown Seaweed Lipids on Fatty Acid Composition and Lipid Hydroperoxide Levels of Mouse Liver
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DOI：
10.1021/jf104643b
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发表时间：
2011-04-27
影响因子：
6.1
通讯作者：
Miyashita, Kazuo
中科院分区：
文献类型：
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作者：
Airanthi, M. K. Widjaja-Adhi;Sasaki, Naoya;Miyashita, Kazuo
裙带菜（Wakame），霍氏马尾藻（Akamoku），和Hakodatensis（Uganomoku）的棕色海藻脂质含有几种生物活性化合物，即岩藻黄素，多酚，和ω-3多不饱和脂肪酸（PUPA）。岩藻黄素和多酚含量的Akamoku和Uganomoku脂质高于那些的裙带菜脂质，而裙带菜脂质表现出较高的总ω-3多不饱和脂肪酸含量比Akamoku和Uganomolcu脂质。Akamoku和Uganomoku脂饲使KK-A（y）小鼠肝脂中二十二碳六烯酸（DHA）和花生四烯酸（AA）含量显著升高，而Wakame脂饲则无此作用。据报道，岩藻黄质可加速ω-3 PUFA和ω-6 PUPA分别生物转化为DHA和AA。喂食Akamoku和Uganomoku脂质的小鼠的较高的肝脏DHA和AA水平将归因于Akamoku和Uganomoku脂质的较高的岩藻黄素含量。喂食褐藻脂质的小鼠肝脏的脂质过氧化氢水平显著低于对照小鼠，尽管喂食褐藻脂质的小鼠肝脏中的总PUFA含量较高。这至少部分是由于肝脏中岩藻黄质代谢物的抗氧化活性。
Brown seaweed lipids from Undaria pinnahfida (Wakame), Sargassum horneri (Akamoku), and Cystoseira hakodatensis (Uganomoku) contained several bioactive compounds, namely, fucoxanthin, polyphenols, and omega-3 polyunsaturated fatty acids (PUPA). Fucoxanthin and polyphenol contents of Akamoku and Uganomoku lipids were higher than those of Wakame lipids, while Wakame lipids showed higher total omega-3 PUFA content than Akamoku and Uganomolcu lipids. The levels of docosahexaenoic acid (DHA) and arachidonic acid (AA) in liver lipids of KK-A(y) mouse significantly increased by Akamoku and Uganomoku lipid feeding as compared with the control, but not by Wakame lipid feeding. Fucoxanthin has been reported to accelerate the bioconversion of omega-3 PUFA and omega-6 PUPA to DHA and AA, respectively. The higher hepatic DHA and AA level of mice fed Akamoku and Uganomoku lipids would be attributed to the higher content of fucoxanthin of Akamoku and Uganomoku lipids. The lipid hydroperoxide levels of the liver of mice fed brown seaweed lipids were significantly lower than those of control mice, even though total PUFA content was higher in the liver of mice fed brown seaweed lipids. This would be, at least in part, due to the antioxidant activity of fucoxanthin metabolites in the liver.