T2 Relaxation Time Abnormalities in Bipolar Disorder and Schizophrenia
T2 Relaxation Time Abnormalities in Bipolar Disorder and Schizophrenia
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DOI：
10.1002/mrm.22148
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发表时间：
2010-01-01
影响因子：
3.3
通讯作者：
Olson, David P.
中科院分区：
文献类型：
--
作者：
Ongur, Dost;Prescot, Andrew P.;Olson, David P.
双相情感障碍和精神分裂症患者的皮质神经元和神经胶质细胞的数量、密度和大小存在显着异常。由于分子-微环境相互作用会调节代谢物信号特征，因此这些细胞异常可能会影响横向 (T(2)) 弛豫时间。我们在 4 T 下测量了 20 名健康受试者、15 名双相情感障碍患者和 15 名精神分裂症患者的前扣带皮层和顶枕皮层中三种细胞内代谢物（N-乙酰天冬氨酸 + N-乙酰天冬氨酰谷氨酸、肌酸 + 磷酸肌酸和含胆碱化合物）的 T(2) 弛豫时间。 T(2) 定量是从具有不同回波时间（30 至 500 毫秒，以 10 毫秒为步长）的 8 cc 体素中收集的。双相情感障碍和精神分裂症组的 T(2) 弛豫时间在数值上都比这两个地区的健康受试者组短。对于双相情感障碍中的肌酸+磷酸肌酸和含胆碱化合物以及精神分裂症中的含胆碱化合物，这些差异达到了统计学显着性。代谢物 T(2) 弛豫时间缩短与细胞体积减少和大分子结构改变一致，并且与双相情感障碍和精神分裂症中报道的水 T(2) 弛豫时间延长一致。这些发现表明，精神疾病磁共振波谱研究中报告的代谢物浓度可能会受到 T(2) 弛豫的影响，并强调了测量和校正该变量的重要性。 Magn Reson Med 63:1-8, 2010。(C) 2009 Wiley-Liss, Inc.
There are substantial abnormalities in the number, density, and size of cortical neurons and glial cells in bipolar disorder and schizophrenia. Because molecule-microenvironment interactions modulate metabolite signals characteristics, these cellular abnormalities may impact transverse (T(2)) relaxation times. We measured T(2) relaxation times for three intracellular metabolites (N-acetylaspartate + N-acetylaspartylglutamate, creatine + phosphocreatine, and choline-containing compounds) in the anterior cingulate cortex and parieto-occipital cortex from 20 healthy subjects, 15 patients with bipolar disorder, and 15 patients with schizophrenia at 4 T. Spectra used in T(2) quantification were collected from 8-cc voxels with varying echo times (30 to 500 ms, in 10-ms steps). Both bipolar disorder and schizophrenia groups had numerically shorter T(2) relaxation times than the healthy subjects group in both regions; these differences reached statistical significance for creatine + phosphocreatine and choline-containing compounds in bipolar disorder and for choline-containing compounds in schizophrenia. Metabolite T(2) relaxation time shortening is consistent with reduced cell volumes and altered macromolecule structures, and with prolonged water T(2) relaxation times reported in bipolar disorder and schizophrenia. These findings suggest that metabolite concentrations reported in magnetic resonance spectroscopy studies of psychiatric conditions may be confounded by T(2) relaxation and highlight the importance of measuring and correcting for this variable. Magn Reson Med 63:1-8, 2010. (C) 2009 Wiley-Liss, Inc.