Age-Related Morphological Changes in Smooth Muscle and Collagen Content in Human Corpus Cavernosum
Age-Related Morphological Changes in Smooth Muscle and Collagen Content in Human Corpus Cavernosum
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DOI：
10.1111/j.1743-6109.2009.01508.x
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发表时间：
2010-08-01
影响因子：
3.5
通讯作者：
Herrera, Ana Milena
中科院分区：
文献类型：
--
作者：
Ferrer, Julio Eduardo;Velez, Juan Diego;Herrera, Ana Milena
导论.勃起功能障碍（艾德）的发生与衰老有关，可能与阴茎海绵体的形态学改变有关。评估人阴茎海绵体中平滑肌和胶原含量并将其与年龄相关联。在1年期间收集尸体人海绵体组织。对整个阴茎海绵体的组织切片进行形态学分析，用Masson三色法染色，以区分平滑肌（红色）和胶原（蓝色）的含量。用专门的显微照片图像分析软件进行分析。Pearson相关性检验用于建立阴茎海绵体形态（平滑肌和胶原含量）与年龄之间的相关性。共分析了来自不同男性尸体的89个组织样本。样本的平均年龄为49.2 +/- 19.1岁，范围在14至90岁之间。年龄与平滑肌含量百分比呈负相关（P = 0.012），与胶原含量百分比呈正相关（P = 0.019），与平滑肌与胶原含量比值呈负相关（P = 0.007）。在人阴茎海绵体中观察到平滑肌和胶原蛋白含量方面的平滑肌相关形态学变化，这可能是ED. Ferrer JE，Velez JD和Herrera AM发展的一个促成因素。阴茎海绵体平滑肌形态学及胶原含量的变化。J Sex Med 2010;7：2723-2728.
Introduction. Aging process has been related to erectile dysfunction (ED) possibly due to morphological changes in corpus cavernosum among many other causes.Aim. To evaluate smooth muscle and collagen content in human corpus cavernosum and to correlate it to age.Methods. Cadaveric human cavernosal tissue was collected during the period of 1 year. Morphological analysis of a whole corpus cavernosum was performed in tissue sections stained with Masson's trichromic method to differentiate smooth muscle (red) from collagen (blue) content.Main Outcome Measures. Analysis was performed with specialized micrographs image analysis software. Pearson's correlation test was used to establish correlation between corpus cavernosum morphology (smooth muscle and collagen content) and age.Results. A total sample of 89 tissues from different male cadavers were analyzed. The average age of the sample was 49.2 +/- 19.1 years, with a range between 14 and 90 years. There was a statistically significant inverse correlation between age and the percentage of smooth muscle content (P = 0.012), direct correlation between age and percentage of collagen content (P = 0.019), and inverse correlation between age and the ratio of smooth muscle : collagen content (P = 0.007).Conclusions. Age-related morphological changes in terms of smooth muscle and collagen content are observed in human corpus cavernosum as a possible contributing factor to the development of ED. Ferrer JE, Velez JD, and Herrera AM. Age-related morphological changes in smooth muscle and collagen content in human corpus cavernosum. J Sex Med 2010;7:2723-2728.