A single-nucleotide polymorphism of the TNFSF4 gene is associated with systemic lupus erythematosus in Chinese Han population
A single-nucleotide polymorphism of the TNFSF4 gene is associated with systemic lupus erythematosus in Chinese Han population
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DOI：
10.1007/s00296-009-1247-2
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发表时间：
2011-02
影响因子：
4
通讯作者：
Shengquan Zhang;Jian-Wen Han;Liangdan Sun;Wen-sheng Lu;X. Yin;Xuejun Zhang;Sen Yang
中科院分区：
文献类型：
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作者：
Shengquan Zhang;Jian-Wen Han;Liangdan Sun;Wen-sheng Lu;X. Yin;Xuejun Zhang;Sen Yang
Systemic lupus erythematosus (SLE) is a prototypic autoimmune disease with complex genetic inheritance. Recently, single-nucleotide polymorphisms (SNPs) in tumor necrosis factor (TNF) superfamily gene TNFSF4 have been shown to be associated with SLE in European and Hong Kong Chinese populations. But it is unknown whether it is also associated with the disease in Mainland Chinese Han population. We genotyped the SNPs rs1234315 near the TNFSF4 gene in 1,344 SLE patients and 4,315 controls of Chinese Han population and confirmed the association between the SNP and the SLE [odds ratios (ORs) of 1.45 andPvalues of 1.5 × 10−16]. The stratification analyses showed that rs1234315 was more strongly associated with SLE patients with arthritis. Our study not only suggested that the TNFSF4 gene was associated with SLE in Chinese Han population, but also implied that it might be a common genetic factor predisposing to the development of SLE in multiple populations.
