A sugar's choice: coordination to a mononuclear or a dinuclear copper(II) complex?
A sugar's choice: coordination to a mononuclear or a dinuclear copper(II) complex?
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糖的选择：与单核或双核铜（II）配合物配位？
DOI：
10.1021/ic048724p
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发表时间：
2005
影响因子：
4.6
通讯作者：
Michael Dittel
中科院分区：
文献类型：
--
作者：
S. Striegler;Michael Dittel
我们提出了碳水化合物配位铜（II）配合物糖结合位点上金属离子数量的决定性作用。为了验证这一假设，我们研究了代表性选择的碳水化合物 D-核糖 (7)、D-甘露糖 (8)、D-葡萄糖 (9) 和 D-麦芽糖 (10) 在碱性溶液中与结构相关的单核和双核铜 (II) 配合物的结合。所有碳水化合物以 1:1 摩尔比与金属络合物配位。 7或8与双核铜(II)配合物1的配位比与相关单核配合物形成的配合物强约0.5个数量级。相反，9（8 的差向异构体）在碱性水溶液中与任一单核铜（II）配合物的配位更强。
We proposed a decisive role of the number of metal ions at the sugar binding site for carbohydrate-coordinating copper(II) complexes. To verify this hypothesis, we studied the binding of the representatively chosen carbohydrates D-ribose (7), D-mannose (8), D-glucose (9), and D-maltose (10) to structurally related mono- and dinuclear copper(II) complexes in alkaline solution. All carbohydrates coordinate to the metal complexes in a 1:1 molar ratio. Coordination of 7 or 8 to the dinuclear copper(II) complex 1 is about 0.5 order of magnitude stronger than the complex formation with related mononuclear complexes. On contrast, 9, which is an epimer of 8, coordinates stronger to either one of the mononuclear copper(II) complexes in alkaline aqueous solution.