Toward using iPS cells to treat spinal cord injury: Their safety and therapeutic efficacy
Toward using iPS cells to treat spinal cord injury: Their safety and therapeutic efficacy
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DOI：
10.2492/inflammregen.31.2
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发表时间：
2011
影响因子：
8.1
通讯作者：
Kyoko Miura;Osahiko Tsuji;M. Nakamura;H. Okano
中科院分区：
文献类型：
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作者：
Kyoko Miura;Osahiko Tsuji;M. Nakamura;H. Okano
脊髓是中枢神经系统的一部分，被认为是再生困难的器官的典型例子。然而，自从报道了大鼠胎儿来源的神经干/祖细胞（NS/PC）的细胞移植导致脊髓损伤（SCI）模型中的功能恢复以来，干细胞移植疗法吸引了恢复和补充丢失的神经元和神经胶质的巨大希望。近年来，通过将几种不同的基因导入体细胞，已经产生了具有胚胎干细胞样多能性和增殖能力的诱导多能干细胞（iPS）。目前，以细胞移植治疗为目的的iPS细胞的研究进展迅速，相继出现了开发诱导人iPS细胞分化为各种体细胞的方法和用小鼠iPS细胞治疗小鼠模型的病例的报道。然而，从安全性的观点来看，由于ES细胞和iPS细胞都是多能干细胞而产生的问题以及人工重编程的iPS细胞所特有的许多问题仍然没有解决，并且期望在研究中取得进一步的进展。在本文中，我们概述了这些问题，并报告了最新的研究结果方面的应用，以治疗脊髓损伤。
The spinal cord, which is part of the central nervous system, has been considered a typical example of an organ in which regeneration is difficult. However, since the report of recovery of function in a spinal cord injury (SCI) model as a result of cell transplantation of rat-fetus-derived neural stem/progenitor cells (NS/PCs), stem cell transplantation therapy has attracted great hope of restoring and replenishing lost neurons and glia. In recent years induced pluripotent stem (iPS) cells that possess embryonic stem (ES)-cell-like pluripotency and proliferative capacity have been produced by introducing several different genes into somatic cells. Rapid progress is currently being made in research on iPS cells with the aim of enabling cell transplantation therapy, and reports of the development of methods of inducing human iPS cells to differentiate into a variety of somatic cells and cases of treatment of murine models with mouse iPS cells have appeared one after another. However, when viewed from a safety standpoint, problems that arise because ES cells and iPS cells are both pluripotent stem cells and many problems unique to iPS cells, which have been artificially reprogrammed, still remain unresolved, and there is a desire for further progress in research. In this paper we outline these issues and report the latest findings in regard to application to the treatment of spinal cord injury.