In Vivo MR Elastography of the Prostate Gland Using a Transurethral Actuator
In Vivo MR Elastography of the Prostate Gland Using a Transurethral Actuator
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DOI：
10.1002/mrm.22038
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发表时间：
2009-09-01
影响因子：
3.3
通讯作者：
Plewes, Donald
中科院分区：
文献类型：
--
作者：
Chopra, Rajiv;Arani, Arvin;Plewes, Donald
使用表面驱动器的MR弹性成像（MRE）的常规方法由于衰减而难以在前列腺中实现足够的剪切波传播。在这项研究中，我们评估的可行性产生剪切波传播的前列腺使用经尿道装置。提出了一种新的经尿道致动器设计，并在明胶体模和犬前列腺中评价了该装置的性能。所有MRI均在1.5T MR成像仪上使用常规梯度回波MRE序列进行。使用压电陶瓷致动器使经尿道器械沿着其长度振动。剪切波传播测量横向和平行于杆在100和250 Hz之间的频率在幻影和前列腺。剪切波传播是圆柱形的，并且在凝胶实验中沿杆的整个长度沿着是均匀的。在犬模型中证明了经尿道MRE的可行性，并在前列腺中以及沿着杆观察到剪切波传播。这些实验证明了经尿道MRE在体内的技术可行性。这项技术的进一步发展是必要的。Magn Reson Med 62：665-671，2009。(C)2009 Wiley-Liss，Inc.
Conventional approaches for MR elastography (MRE) using surface drivers have difficulty achieving sufficient shear wave propagation in the prostate gland due to attenuation. In this study we evaluate the feasibility of generating shear wave propagation in the prostate gland using a transurethral device. A novel transurethral actuator design is proposed, and the performance of this device was evaluated in gelatin phantoms and in a canine prostate gland. All MRI was performed on a 1.5T MR imager using a conventional gradient-echo MRE sequence. A piezoceramic actuator was used to vibrate the transurethral device along its length. Shear wave propagation was measured transverse and parallel to the rod at frequencies between 100 and 250 Hz in phantoms and in the prostate gland. The shear wave propagation was cylindrical, and uniform along the entire length of the rod in the gel experiments. The feasibility of transurethral MRE was demonstrated in vivo in a canine model, and shear wave propagation was observed in the prostate gland as well as along the rod. These experiments demonstrate the technical feasibility of transurethral MRE in vivo. Further development of this technique is warranted. Magn Reson Med 62: 665-671, 2009. (C) 2009 Wiley-Liss, Inc.