The use of the restricted partition method with case-control data
The use of the restricted partition method with case-control data
复制标题
DOI：
10.1159/000099181
复制
发表时间：
2007-01-01
期刊：
影响因子：
1.8
通讯作者：
Culverhouse, R.
中科院分区：
文献类型：
--
作者：
Culverhouse, R.
背景/目的：许多对公共卫生重要的疾病并不仅仅是由于单一的突变或环境的损害。相反，多种基因和环境暴露之间的复杂相互作用可能在从精神分裂症到化疗反应的各种表型的病因学中起着至关重要的作用。限制分割法（RPM）旨在检测定量性状的遗传和环境定性因素，即使这些贡献主要表现为相互作用（在单变量分析中显示很少或没有信号）。虽然RPM的开发期望性状值将从正态分布中提取，但如果将定量性状值替换为表示控制或情况状态的0或1，该算法将发挥作用。本研究的目的是评估RPM在病例对照数据上的表现。方法：本研究模拟的病例对照数据和提供给2005年药物遗传学研究网络分析研讨会的数据被用来评估这种情况下RPM的功率和I型误差。结果：对于测试数据，RPM显示良好的功率和I型误差非常接近标称速率。结论：RPM是一种适合病例对照资料分析的方法。版权所有(c) 2007 S. Karger AG，巴塞尔。
Background/Aims: Many diseases important to public health are not due solely to a single mutation or environmental insult. Instead, complex interactions among multiple genes and environmental exposures likely play crucial roles in the etiology of diverse phenotypes from schizophrenia to chemotherapy response. The Restricted Partition Method ( RPM) was designed to detect qualitative genetic and environmental factors contributing to a quantitative trait, even if the contribution is predominantly presented as an interaction (displaying little or no signal in univariate analyses). Although the RPM was developed with the expectation that trait values would be drawn from normal distributions, the algorithm will function if the quantitative trait values are replaced with 0's or 1's indicating control or case status. The aim of this study is to evaluate the performance of the RPM on case-control data. Methods: Case-control data simulated for this study and data provided to the Pharmcogenetics Research Network Analysis Workshop 2005 were used to assess power and type I error for the RPM in this setting. Results: For the tested data, the RPM displayed good power and type I error very close to nominal rates. Conclusions: The RPM is an appropriate method for the analysis of case-control data. Copyright (c) 2007 S. Karger AG, Basel.