RepliVAX WN, a single-cycle flavivirus vaccine to prevent West Nile disease, elicits durable protective immunity in hamsters.
RepliVAX WN, a single-cycle flavivirus vaccine to prevent West Nile disease, elicits durable protective immunity in hamsters.
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RepliVAX WN 是一种预防西尼罗河病的单周期黄病毒疫苗，可在仓鼠中激发持久的保护性免疫力。
DOI：
10.1016/j.vaccine.2009.07.016
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发表时间：
2009
期刊：
影响因子：
5.5
通讯作者：
Mason,PeterW
中科院分区：
文献类型：
--
作者：
Widman,DouglasG;Ishikawa,Tomohiro;Winkelmann,EvandroR;Infante,Ernesto;Bourne,Nigel;Mason,PeterW
西尼罗河病毒（WNV）引起严重的疾病，但没有疫苗可以预防人类的WN疾病。我们以前曾报道过，在WN疾病的小鼠和仓鼠模型中，<$VAX WN是一种安全有效的疫苗。在这里，我们报告说，用VAX WN接种仓鼠会诱导抗体反应，并在至少6个月内保持稳定。此外，在接种后6个月用毒性WNV攻击的动物以及在接种后2个月攻击的那些动物都受到保护免于疾病，没有接种疫苗的动物死于WNV攻击。这些结果表明，dVAX能够在单次给药后诱导持久的保护性免疫。
West Nile virus (WNV) causes significant disease, yet no vaccines exist to prevent WN disease in humans. We have previously reported that RepliVAX WN is a safe and efficacious vaccine in mouse and hamster models of WN disease. Here, we report that vaccination of hamsters with RepliVAX WN induces antibody responses that remain stable for at least 6 months. Furthermore, animals challenged with virulent WNV 6 months after vaccination were protected from disease as well as those challenged 2 months post-vaccination, with no vaccinated animals succumbing to WNV challenge. These results indicate that RepliVAX is capable of inducing durable protective immunity after a single dose.