Effects of Lactoferrin on Subjective Skin Conditions in Winter: A Preliminary, Randomized, Double-Blinded, Placebo-Controlled Trial
Effects of Lactoferrin on Subjective Skin Conditions in Winter: A Preliminary, Randomized, Double-Blinded, Placebo-Controlled Trial
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DOI：
10.2147/ccid.s228153
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发表时间：
2019-01-01
影响因子：
2.3
通讯作者：
Nomiyama, Tetsuo
中科院分区：
文献类型：
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作者：
Oda, Hirotsugu;Miyakawa, Momoko;Nomiyama, Tetsuo
目的：研究乳铁蛋白（LF）对冬季主观皮肤状况的影响。设计：一项初步、随机、双盲、安慰剂对照试验。设置和受试者：日本健康成人。干预措施：在冬季摄入安慰剂、200 mg或600 mg LF，持续12周。终点：主观皮肤状况评分的变化。结果：346例受试者被随机分组。9例受试者（安慰剂组，n=0; 200 mg组，n=5; 600 mg组，n=4）撤回知情同意书，7例受试者（安慰剂组，n=4; 200 mg组，n=2; 600 mg组，n=1）失访，导致全分析集为330例。水分的分数的变化在200毫克和600毫克组，质地的变化在600毫克组比安慰剂组在女性subjects.Conclusion：LF的摄入量可能会改善水分或纹理的皮肤在冬季。
Objective: To investigate the effects of lactoferrin (LF) on subjective skin conditions in winter.Design: A preliminary, randomized, double-blinded, placebo-controlled trial.Setting and subjects: Healthy adults in Japan.Interventions: Intake of placebo, 200 mg, or 600 mg of LF for 12 weeks in winter.Endpoints: Changes in the scores of subjective skin conditions.Results: Three hundred and forty-six subjects were randomized. Nine subjects (placebo, n=0; 200 mg, n=5; 600 mg, n=4) withdrew consent, and 7 subjects (placebo, n=4; 200 mg, n=2; 600 mg, n=1) were lost to follow-up, resulting in 330 for a full analysis set.Outcomes: Changes in the scores of moisture were greater in the 600 mg group than in the placebo group. Changes in the scores of moisture were greater in the 200 mg and 600 mg groups, and of texture were greater in the 600 mg group than in the placebo group in female subjects.Conclusion: Intake of LF may improve moisture or texture of skin in winter.