Metabolic Syndrome, Brain Magnetic Resonance Imaging, and Cognition
Metabolic Syndrome, Brain Magnetic Resonance Imaging, and Cognition
复制标题
DOI：
10.2337/dc10-0851
复制
发表时间：
2010-12-01
期刊：
影响因子：
16.2
通讯作者：
Schmidt, Reinhold
中科院分区：
文献类型：
--
作者：
Cavalier, Margherita;Ropele, Stefan;Schmidt, Reinhold
目的 - 我们探讨了与脑磁共振成像 (MRI) 结果相关的代谢综合征中的认知障碍 研究设计和方法 - 我们研究了基于人群的澳大利亚中风预防研究中 819 名没有临床中风和痴呆症的参与者，他们接受了脑部 MRI 神经心理学测试和与国家胆固醇教育计划成人治疗小组 III 标准定义的代谢综合征相关的危险因素评估，还确定了高敏 C 反应蛋白 (hs-CRP) 结果- 819 名受试者中，232 名 (28±3%) 患有代谢综合征 调整可能的混杂因素后，在评估记忆和执行功能的认知测试中，他们的表现比没有代谢综合征的人差 按性别分层表明，代谢综合征与男性认知功能障碍相关，但与女性无关 只有男性中，代谢综合征成分的数量不断增加，与较差的认知表现相关 MRI 显示患有和不患有代谢综合征的受试者之间局灶性缺血性病变和脑容量没有显着差异，MRI 异常无法解释认知能力受损结论 - 代谢综合征对没有临床中风或没有痴呆的社区居民受试者的记忆和执行功能产生不利影响，男性比女性更容易受到影响，特别是如果他们有高炎症标志物，MRI 检测到的大脑异常在这些关系中并不起关键作用
OBJECTIVE - We explored cognitive impairment in metabolic syndrome in relation to brain magnetic resonance imaging (MRI) findingsRESEARCH DESIGN AND METHODS - We studied 819 participants free of clinical stroke and dementia of the population-based Austrain Stroke Prevention Study who had under gone brain MRI neuropsychological testing and a risk factor assessment relevant to National Cholesterol Education Program Adult Treatment Panel III criteria defined metabolic syndrome High-sensitivity C reactive protein (hs-CRP) was also determinedRESULTS - Of 819 subjects 232 (28 3%) had metabolic syndrome They performed worse than those without metabolic syndrome on cognitive tests assessing memory and executive functioning after adjustment for possible confounders Stratification by sex demonstrated that metabolic syndrome was related to cognitive dysfunction in men but not in women Only in men was an increasing number of metabolic syndrome components associated with worse cognitive performance MRI showed no significant difference in focal ischemic lesions and brain volume between subjects with and without metabolic syndrome and MRI abnormalities failed to explain impaired cognition Cognitive performance was most affected in male subjects with metabolic syndrome who also had high hs-CRP levelsCONCLUSIONS - Metabolic syndrome exerts detrimental effects on memory and executive functioning in community-dwelling subjects who have not had a clinical stroke or do not have dementia Men are more affected than women particularly if they have high inflammatory markers MRI detected brain abnormalities do not play a crucial role in these relationships