AIDS wasting syndrome: Trends, influence on opportunistic infections, and survival
AIDS wasting syndrome: Trends, influence on opportunistic infections, and survival
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DOI：
10.1097/00126334-200306010-00024
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发表时间：
2003-06-01
影响因子：
3.6
通讯作者：
Williamson, JM
中科院分区：
文献类型：
--
作者：
Dworkin, MS;Williamson, JM
作者检查了来自一个大型HIV感染者队列的数据，以证明消耗综合征的最新趋势，检查消耗综合征对其他机会性疾病发生率的影响，并探索是否有任何常见的消耗治疗与改善生存率相关。Kaplan-Meier分析和多变量左截断考克斯模型分别用于估计首次诊断为消耗综合征后至死亡的时间，并量化协变量与死亡率之间的相关性。1992年至1999年期间，消瘦症的发病率有所下降，1995年之后下降幅度最大。艾滋病和非艾滋病界定疾病的发病率在诊断为消耗综合征时或之后通常很高。与生存率提高显著相关的因素包括：在消耗综合征诊断期间，CD 4（+）计数大于或等于200个细胞/L，以及在诊断消耗综合征时或之后使用两种或多种药物进行抗逆转录病毒治疗。氧雄龙处方与改善生存，但结果并没有完全达到统计学意义。作者的研究提供了支持性信息，即治疗消耗综合征可能对生存率有有利影响。
The authors examined data from a large cohort of HIV-infected persons to demonstrate recent trends in wasting syndrome, to examine the influence of wasting syndrome on the incidence of other opportunistic illnesses, and to explore if any of the commonly prescribed treatments for wasting are associated with improved survival. Kaplan-Meier analysis and multivariate left-truncated Cox models were used to estimate time to death after the first diagnosis of wasting syndrome and to quantify the association between the covariate and mortality, respectively. The incidence of wasting declined during 1992 through 1999, with the most marked rate of decline occurring after 1995. The incidence of AIDS- and non-AIDS-defining illnesses was generally high at or after a diagnosis of wasting syndrome. Factors significantly associated with improved survival include having a CD4(+) count of greater than or equal to200 cells/L during the interval of the wasting syndrome diagnosis and antiretroviral therapy with two or more drugs at or after the diagnosis of wasting syndrome. Prescription of oxandrolone was associated with improved survival, but the results did not quite reach statistical significance. The authors' study provides supportive information that treatment of wasting syndrome may have a favorable impact on survival.