Changes in Radiation Dose with Variations in Human Anatomy: Moderately and Severely Obese Adults
Changes in Radiation Dose with Variations in Human Anatomy: Moderately and Severely Obese Adults
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DOI：
10.2967/jnumed.109.073015
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发表时间：
2010-06-01
影响因子：
9.3
通讯作者：
Brill, Aaron B.
中科院分区：
文献类型：
--
作者：
Clark, Landon D.;Stabin, Michael G.;Brill, Aaron B.
标准化剂量评估中使用的模型基于中位数（即，第50百分位）的个体，例如，成年男性或女性或特定年龄的儿童。在这里，我们描述的模型，而不是肥胖对特定吸收分数（SAF）和剂量因子在成人的影响。研究方法：回顾文献，以评估轻度和重度肥胖成年男性和女性个体器官大小如何随体重变化而变化。在文献评价的基础上，对我们的可变形参考成年男性和女性全身模型进行了变更。进行了辐射输运的Monte Carlo模拟。为轻度和重度肥胖成年人生成光子SAF，并与参考（第50百分位数）SAF值进行比较。结果如下：肥胖体模和第50百分位数参考体模之间研究的SAF与第50百分位数参考个体之间没有显著差异，除了肠照射一些腹部器官，因为肠系膜脂肪沉积增加引起的褶皱之间的分离增加。某些器官对的一些低能量值是不同的，可能只是由于这些低能量下数据的统计变异性。结论：肥胖对内部发射体剂量计算的影响很小，在常规使用标准化剂量估计时可能会被忽略。
The phantoms used in standardized dose assessment are based on a median (i.e., 50th percentile) individual of a large population, for example, adult males or females or children of a particular age. Here we describe phantoms that model instead the influence of obesity on specific absorbed fractions (SAFs) and dose factors in adults. Methods: The literature was reviewed to evaluate how individual organ sizes change with variations in body weight in mildly and severely obese adult men and women. On the basis of the literature evaluation, changes were made to our deformable reference adult male and female total-body models. Monte Carlo simulations of radiation transport were performed. SAFs for photons were generated for mildly and severely obese adults, and comparisons were made to the reference (50th) percentile SAF values. Results: SAFs studied between the obese phantoms and the 50th percentile reference phantoms were not significantly different from the reference 50th percentile individual, with the exception of intestines irradiating some abdominal organs, because of an increase in separation between folds caused by an increase in mesenteric adipose deposits. Some low-energy values for certain organ pairs were different, possibly due only to the statistical variability of the data at these low energies. Conclusion: The effect of obesity on dose calculations for internal emitters is minor and may be neglected in the routine use of standardized dose estimates.