1,6-Conjugate sulfonylation of para-quinone methides: An expedient approach to unsymmetrical gem-diarylmethyl sulfones
1,6-Conjugate sulfonylation of para-quinone methides: An expedient approach to unsymmetrical gem-diarylmethyl sulfones
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DOI：
10.1016/j.tetlet.2018.12.023
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发表时间：
2019-01-17
影响因子：
1.8
通讯作者：
Liu, Zhang-Qin
中科院分区：
文献类型：
--
作者：
Guan, Xiao-Yu;Zhang, Liang-Dong;Liu, Zhang-Qin
研究了芳香亚磺酸钠与对苯醌甲基化物的磺酰化反应。该反应提供了一种廉价、高效的合成不对称二芳基甲基砜的方法，具有原子经济性高、官能团耐受性好、可扩展性好、操作环境友好等优点。目标产物的衍生物也被证明。(C)2018爱思唯尔有限公司版权所有。
A novel sulfonylation of para-quinone methides with sodium arylsulfinates has been developed via acetic acid promoted sulfa-Michael addition. This reaction provides an inexpensive and efficient method to synthesize various unsymmetrical diarylmethyl sulfones, displaying the advantages of high atom economy, good functional group tolerance, scalability, and environmentally friendly operation. Derivations of target products are also demonstrated. (C) 2018 Elsevier Ltd. All rights reserved.