Effect of increased maternal corticosterone during lactation on hippocampal corticosteroid receptors, stress response and learning in offspring in the early stages of life
Effect of increased maternal corticosterone during lactation on hippocampal corticosteroid receptors, stress response and learning in offspring in the early stages of life
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DOI：
10.1016/s0306-4522(96)00668-9
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发表时间：
1997-08-01
期刊：
影响因子：
3.3
通讯作者：
Catalani, A
中科院分区：
文献类型：
--
作者：
Casolini, P;Cigliana, G;Catalani, A
研究了哺乳期母体皮质酮对大鼠海马皮质类固醇受体系统、下丘脑-垂体-肾上腺轴活性和空间学习/保持性能的影响。我们通过向母鼠的饮用水中添加激素（200 μ g/ml）来增加血浆皮质酮水平。与对照组相比，皮质酮喂养的后代显示：i）在出生后30天时海马I型和II型皮质类固醇受体的数量较高，但在11天和16天时没有变化; ii）在基础条件下和在母体分离15分钟后，ii时皮质酮的血浆水平较高，但在16天时没有变化; iii）在11和16日龄时肾上腺重量较低，但在30日龄时不再存在; iv）在16天时，在Morris水任务和T水迷宫的位置学习版本中的表现没有差异。与我们先前的发现一起表明90天大的皮质酮喂养的大鼠具有较低的基础和束缚应激皮质酮水平以及改善的学习表现，表明母体处理的效果仅在断奶后出现，从而表明增加的皮质类固醇受体可能是原因，至少部分是因为断奶前暴露于皮质酮引起的内分泌和学习改变。在哺乳期的母亲循环皮质酮在塑造下丘脑-垂体-肾上腺轴和大脑的后代的特点所发挥的作用进行了概述。(C)1997年IBRO。出版社：Elsevier Science Ltd
The influence of maternal corticosterone during lactation on the development of the hippocampal corticosteroid receptor system, hypothalamus-pituitary-adrenal axis activity and spatial learning/retention performance was investigated in the rat during postnatal days Il to 30. We increased the plasma levels of corticosterone by adding the hormone (200 mu g/ml) to the drinking water of the dams. When compared to controls corticosterone-nursed offspring displayed: i) higher number of hippocampal type I and type II corticosteroid receptors at 30 days of life, but no changes at 11 and 16 days; ii) higher plasma levels of corticosterone in the basal condition and after 15 min of maternal separation at ii but not at 16 days; iii) lower adrenal weights at 11 and 16 days, but which were no longer present at the age of 30 days; iv) no difference in performance in the place learning version of the Morris water task and T aquatic maze at 16 days.The present results, together with our previous findings showing that 90-day-old corticosterone-nursed rats have lower basal and restraint stress corticosterone levels and improved learning performance, indicate that the effects of maternal treatment appears only after weaning, thereby suggesting that increased corticosteroid receptors may be responsible, at least partially, for the endocrine and learning modifications induced by pre-weaning corticosterone exposure. The role played by maternal circulating corticosterone during the period of lactation in shaping the characteristics of the hypothalamus-pituitary-adrenal axis and brain of the offspring is outlined. (C) 1997 IBRO. Published by Elsevier Science Ltd.