HYPERINTENSE GLOBUS-PALLIDUS ON T1-WEIGHTED MRI IN CIRRHOTIC-PATIENTS IS ASSOCIATED WITH SEVERITY OF LIVER-FAILURE
HYPERINTENSE GLOBUS-PALLIDUS ON T1-WEIGHTED MRI IN CIRRHOTIC-PATIENTS IS ASSOCIATED WITH SEVERITY OF LIVER-FAILURE
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DOI：
10.1212/wnl.43.1_part_1.65
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发表时间：
1993-01-01
期刊：
影响因子：
9.9
通讯作者：
TOLOSA, E
中科院分区：
文献类型：
--
作者：
PUJOL, A;PUJOL, J;TOLOSA, E
在大多数晚期肝病患者中，t1加权MRI显示苍白球高信号。我们评估了77例符合肝移植条件的患者苍白球信号强度与临床或实验室数据之间的关系。该信号的强度与Child-Pugh评分（作为肝病严重程度的指标）、体位性震颤、静脉曲张出血或肝性脑病的既往发作、凝血酶原活性、血清天冬氨酸和丙氨酸氨基转移酶、胆红素和吲哚菁绿（ICG）肝清除率（一种非常敏感的肝功能指标）之间存在显著相关性。多因素分析显示，ICG肝脏清除率和既往静脉曲张出血发作与苍白球信号强度独立相关。21例患者移植后10 ~ 20个月复查MRI显示病变全部消失。我们的结论是，高强度的苍白球是继发于肝脏疾病的严重程度，当肝功能恢复正常时是可逆的。
Hyperintense globus pallidus on T1-weighted MRI is present in most patients with advanced liver disease. We evaluated the relationship between the signal intensity of the globus pallidus and clinical or laboratory data of 77 patients eligible for liver transplantation. There was a significant correlation between the intensity of the signal and the Child-Pugh score (as indication of severity of liver disease), presence of postural tremor, previous episodes of variceal bleeding or hepatic encephalopathy, prothrombin activity, serum aspartate and alanine amino-transferase, bilirubin, and the indocyanine green (ICG) hepatic clearance, a very sensitive marker of liver function. The multivariate analysis disclosed that the ICG hepatic clearance and previous episodes of variceal bleeding were independently associated with the signal intensity in the globus pallidus. MRI repeated in 21 patients 10 to 20 months after transplant showed a disappearance of the lesion in all cases. We conclude that the hyperintense globus pallidus is secondary to the severity of the liver disease and is reversible when liver function returns to normal.