Salivary cortisol as a biomarker in stress research
Salivary cortisol as a biomarker in stress research
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DOI：
10.1016/j.psyneuen.2008.10.026
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发表时间：
2009-02-01
影响因子：
3.7
通讯作者：
Kudielka, Brigitte M.
中科院分区：
文献类型：
--
作者：
Hellhammer, Dirk H.;Wuest, Stefan;Kudielka, Brigitte M.
唾液皮质醇经常被用作心理压力的生物标志物。然而，触发下丘脑-垂体-肾上腺轴（HPAA）的心理生物学机制只能通过唾液皮质醇测量间接评估。控制HPAA反应性的不同情况（海马、下丘脑、垂体、肾上腺）及其各自的调节剂、受体或结合蛋白，都可能影响唾液皮质醇的测量。因此，与血液或尿液中血浆ACTH和皮质醇测量值的线性关系不一定存在。在响应条件下尤其如此。本文讨论了几个心理和生物学变量，这可能会导致这种解离，并旨在帮助研究人员在他们的实验中，唾液皮质醇作为HPAA生物标志物的压力的有效性和心理生物学意义。(C)2008爱思唯尔有限公司保留所有权利。
Salivary cortisol is frequently used as a biomarker of psychological stress. However, psychobiological mechanisms, which trigger the hypothalamus-pituitary-adrenal axis (HPAA) can only indirectly be assessed by salivary cortisol measures. The different instances that control HPAA reactivity (hippocampus, hypothalamus, pituitary, adrenals) and their respective modulators, receptors, or binding proteins, may all affect salivary cortisol measures. Thus, a linear relationship with measures of plasma ACTH and cortisol in blood or urine does not necessarily exist. This is particularly true under response conditions. The present paper addresses several psychological and biological variables, which may account for such dissociations, and aims to help researchers to rate the validity and psychobiological significance of salivary cortisol as an HPAA biomarker of stress in their experiments. (C) 2008 Elsevier Ltd. All rights reserved.