Costimulation of naive CD8+ lymphocytes induces CD4 expression and allows human immunodeficiency virus type 1 infection
Costimulation of naive CD8+ lymphocytes induces CD4 expression and allows human immunodeficiency virus type 1 infection
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DOI：
10.1128/jvi.72.11.9054-9060.1998
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发表时间：
1998-11-01
影响因子：
5.4
通讯作者：
Zack, JA
中科院分区：
文献类型：
--
作者：
Kitchen, SG;Korin, YD;Zack, JA
人类免疫缺陷病毒1型（HIV-1）感染需要细胞表面表达CD 1。抗CD 3和抗CD 28抗体或同种异体树突状细胞共刺激CD 8（+）/CD 4（-）T淋巴细胞可诱导CD 4表达，并使这些CD 8细胞对HIV-1感染易感。与CD 45 RO（+）细胞相比，初始CD 45 RA（+）细胞的CD 4表达更高。来自胎儿或新生儿来源的CD 8（+）淋巴细胞表现出更大的倾向于表达CD 4，与其幼稚状态一致。这种感染机制表明，HIV诱导的免疫反应CD 8臂的扰动，并可以解释在HIV感染儿童中观察到的普遍快速的疾病进展。
Human immunodeficiency virus type 1 (HIV-1) infection requires cell surface expression of CD 1. Costimulation of CD8(+)/CD4(-) T lymphocytes by anti-CD3 and anti-CD28 antibodies or by allogeneic dendritic cells induced expression of CD4 and rendered these CD8 cells susceptible to HIV-1 infection. Naive CD45RA(+) cells responded with greater expression of CD4 than did CD45RO(+) cells. CD8(+) lymphocytes derived from fetal or newborn sources exhibited a greater tendency to express CD4, consistent with their naive states. This mechanism of infection suggests HIV-induced perturbation of the CD8 arm of the immune response and could explain the generally rapid disease progression seen in HIV-infected children.