Water removal and solute additions determining increases in renal medullary osmolality.
Water removal and solute additions determining increases in renal medullary osmolality.
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DOI：
10.1152/ajprenal.1983.244.5.f472
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发表时间：
1983-05
期刊：
影响因子：
--
通讯作者：
B. Schmidt-nielsen;B. Graves;J. Roth
中科院分区：
文献类型：
--
作者：
B. Schmidt-nielsen;B. Graves;J. Roth
哺乳动物肾髓质的渗透压和溶质浓度随尿渗透压的变化而增加和减少。这些变化是由于向肾髓质组织中添加或从肾髓质组织中去除溶质或水而引起的。在Munich-Wistar大鼠和叙利亚仓鼠（雄性和雌性）中，测定了这些变化涉及的各种溶质的实际量。从在水利尿和抗利尿的不同阶段处死的动物中取出肾脏。采用一种新的方法分析了肾髓质，该方法允许在同一块组织上测定水和溶质。去除水分和添加尿素是提高内髓渗透压的两个最重要的因素。乳头含水量与乳头渗透压浓度呈负相关，与水利尿相比，极端抗利尿组的乳头含水量低50%。大鼠乳头含水量高于仓鼠。在外髓质，水的去除是显着的仓鼠，但不是在大鼠。在大鼠和仓鼠中，向乳头组织中加入尿素超过NaCl的渗透当量2.8倍。这两个物种的女性表现出更大的变化比男性的量尿素在髓质内。
Osmolality and solute concentrations of the mammalian renal medulla increase and decrease with changing urine osmolality. These changes are brought about by addition or removal of solute or water to or from the renal medullary tissue. In Munich-Wistar rats and Syrian hamsters, males and females, actual amounts of and the various solutes involved in these changes were determined. Kidneys were removed from animals killed in different stages of water diuresis and antidiuresis. The renal medulla was analyzed by a new method that permits determination of water and solutes on the same piece of tissue. Removal of water and addition of urea were the two most important factors in raising inner medullary osmolality. Papillary water content was inversely related to the papillary osmolality and was 50% lower in extreme antidiuresis compared with water diuresis. Rats had higher papillary water content than hamsters. In the outer medulla, water removal was significant in the hamsters but not in the rats. Addition of urea to the papillary tissue exceeded the osmotic equivalent of NaCl by a factor of 2.8 in both rats and hamsters. Females of both species showed greater changes than males in amounts of urea in the inner medulla.