Boosting Antitumour Immunity through Targeted Delivery of Interferon-a.
Boosting Antitumour Immunity through Targeted Delivery of Interferon-a.
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通过干扰素-a 的靶向递送增强抗肿瘤免疫力。
DOI：
10.1016/j.molmed.2019.09.001
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发表时间：
2019
影响因子：
13.6
通讯作者：
Fairchild PJ
中科院分区：
文献类型：
--
作者：
Fairchild PJ
免疫检查点抑制剂（ICI）已经彻底改变了癌症免疫疗法，但它们的成功完全取决于放大针对肿瘤的现有免疫反应。Tsuchiyaet al.提出了如何利用诱导多能干细胞（iPSC）的特性来靶向递送干扰素-α（IFNα）以引发适当的反应。
Immune checkpoint inhibitors (ICIs) have revolutionised cancer immunotherapy but their success is wholly dependent on amplifying an existing immune response directed against the tumour. A recent study by Tsuchiyaet al. suggests how the properties of induced pluripotent stem cells (iPSCs) may be exploited for the targeted delivery of interferon-α (IFNα) to elicit an appropriate response.