FTO Genotype Is Associated with Body Mass Index after the Age of Seven Years But Not with Energy Intake or Leisure-Time Physical Activity
FTO Genotype Is Associated with Body Mass Index after the Age of Seven Years But Not with Energy Intake or Leisure-Time Physical Activity
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DOI：
10.1210/jc.2008-1199
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发表时间：
2009-04-01
影响因子：
5.8
通讯作者：
Ronnemaa, Tapani
中科院分区：
文献类型：
--
作者：
Hakanen, Maarit;Raitakari, Olli T.;Ronnemaa, Tapani
背景：FTO基因的一个常见变异位点rs9939609与成人以及7岁及以上儿童的体重指数（BMI）相关。目的：我们的目的是研究从婴儿期开始随访的儿童中FTO基因型与BMI、心血管危险因素、能量摄入以及休闲时间体力活动的关联。方法：STRIP研究中健康的参与者进行了rs9939609基因分型，从7个月大（n = 640）随访至15岁（n = 438）。这些儿童被随机分配到生活方式干预组和对照组。每年测量身高、体重、血压和血脂。在15岁时获取食物记录和体力活动指数。结果：FTO基因型与7岁以下儿童的BMI无关。从7岁起，A等位基因纯合子的儿童BMI逐渐高于携带一个或两个T等位基因的儿童（FTO与年龄交互作用，P = 0.029）。此外，在纵向的、经BMI Z评分调整的分析中，AA基因型与较高的收缩压和舒张压以及升高的血清总胆固醇和低密度脂蛋白胆固醇相关（主效应分别为P = 0.01、P < 0.001、P = 0.05和P = 0.04）。FTO基因型与15岁时的能量摄入或体力活动指数无关。FTO与研究组的交互作用不显著。结论：我们的结果表明，FTO基因型对BMI的影响在7岁之后才变得明显。这些结果进一步表明，FTO基因与能量摄入或体力活动没有直接关联。（《临床内分泌与代谢杂志》94: 1281 - 1287, 2009）
Context: A common variant in the FTO gene, rs9939609, associates with body mass index (BMI) in adults and in children aged 7 yr or older.Objective: Our aim was to examine the associations of the FTO genotype with BMI, cardiovascular risk factors, energy intake, and leisure-time physical activity in children followed up since infancy.Methods: Healthy participants of the STRIP Study, genotyped for rs9939609, were followed from age 7 months (n = 640) to 15 yr (n = 438). The children were randomly assigned to lifestyle intervention and control groups. Height, weight, blood pressure, and serum lipids were measured annually. Food records and physical activity index were obtained at age 15 yr.Results: The FTO genotype did not associate with BMI in children younger than 7 yr of age. From age 7 yr onward, the children homozygous for the A allele had progressively higher BMI than the children with one or two T alleles (P = 0.029 for FTO by age interaction). Furthermore, in longitudinal, BMI Z-score-adjusted analysis, the AA genotype associated with higher systolic and diastolic blood pressure and with elevated serum total and low-density lipoprotein-cholesterol (P = 0.01, P < 0.001, P = 0.05, and P = 0.04 for main effect, respectively). The FTO genotype did not associate with energy intake or physical activity index at age 15. The FTO*Study group interactions were not significant.Conclusions: Our results suggest that the effect of the FTO genotype on BMI becomes evident only after age 7 yr. These results further suggest that the FTO gene is not directly associated with energy intake or physical activity. (J Clin Endocrinol Metab 94: 1281-1287, 2009)