Protein sequence motifs
Protein sequence motifs
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DOI：
10.1016/s0959-440x(96)80057-1
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发表时间：
1996-06-01
影响因子：
6.8
通讯作者：
Koonin, EV
中科院分区：
文献类型：
--
作者：
Bork, P;Koonin, EV
蛋白质序列基序是蛋白质家族的标志，经常被用作预测蛋白质功能的工具。对已知主题的概括和修改正在成为文献中的主要趋势，尽管新的主题仍在以近似线性的速度被发现。基序分析的重点似乎正在从代谢酶转移到结构和调控蛋白上，在代谢酶中，基序与催化功能相关，因此往往很容易识别，结构和调节蛋白包含更多不同的基序。对结构信息的考虑越来越有助于识别基序及其敏感性。基因组测序为对特定生物体中存在的所有基序进行系统分析提供了基础。因此，系统地派生基序数据库是可行的，允许将大多数新出现的蛋白质序列归入已知家族。
Protein sequence motifs are signatures of protein families and can often be used as tools for the prediction of protein function. The generalization and modification of already known motifs are becoming major trends in the literature, even though new motifs are still being discovered at an approximately linear rate. The emphasis of motif analysis appears to be shifting from metabolic enzymes, in which motifs are associated with catalytic functions and thus often readily recognizable, to structural and regulatory proteins, which contain more divergent motifs. The consideration of structural information increasingly contributes to the identification of motifs and their sensitivity. Genome sequencing provides the basis for asystematic analysis of all motifs that are present in a particular organism. A systematically derived motif database is therefore feasible, allowing the classification of the majority of the newly appearing protein sequences into known families.