Molecular and clinical characteristics of respiratory syncytial virus infections in hospitalized children
Molecular and clinical characteristics of respiratory syncytial virus infections in hospitalized children
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DOI：
10.1007/s00430-003-0215-9
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发表时间：
2005-01-01
影响因子：
5.4
通讯作者：
G端rtler, L
中科院分区：
文献类型：
--
作者：
Mentel, R;Ilgert, U;G端rtler, L
本研究的目的是确定呼吸道合胞病毒（RSV）在德国东北部住院的重要性，并获得循环菌株的分子流行病学数据。使用快速和敏感的逆转录酶-PCR，发现四分之一的儿科呼吸系统疾病入院是由于RSV。在住院患者中由RSV引起的感染在全年进行了测定。在整个期间，RSV A组和B组均以RSV A（86%）为主。通过直接测序推导的氨基酸序列的分析表明，非常相似的RSV株在社区中流通。
The objective of this study was to determine the importance of respiratory syncytial virus (RSV) for hospitalization in the north east of Germany and to obtain molecular epidemiological data of the circulating strains. Using a rapid and sensitive reverse transcriptase-PCR, it was found that a quarter of pediatric respiratory disease admissions were due to RSV. Infections caused by RSV in hospitalized patients were determined over the whole year. Both RSV groups A and B were identified with a predominance of RSV A (86%) over the entire period. The analysis of the deduced amino acid sequences by direct sequencing showed that very similar RSV strains are circulating in the community.