Three controlled trials of interventions to increase recruitment to a randomized controlled trial of mobile phone based smoking cessation support
Three controlled trials of interventions to increase recruitment to a randomized controlled trial of mobile phone based smoking cessation support
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DOI：
10.1177/1740774510367687
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发表时间：
2010-06-01
期刊：
影响因子：
2.7
通讯作者：
Knight, Rosemary
中科院分区：
文献类型：
--
作者：
Free, Caroline;Hoile, Elizabeth;Knight, Rosemary
背景招募是试验的一大挑战，但几乎没有证据表明可以采取干预措施来增加试验招募。我们报告三个对照试验的干预措施，以增加招聘的Txt 2stop trial.Purpose评估：试验1。关于在线登记设施的短信对登记的影响;试验2。向有资格参加试验的受试者发送（原文如此）5封附信对随机化的影响;试验3。随机化的影响短信包含报价从现有participants.Methods单盲对照试验分配隐藏。干预措施：试验1：一条关于我们新的在线注册设施的短信;试验2：一封附有（原文如此）5的信;试验3：一系列包含参与者报价的四条短信。结果试验1：干预组和对照组分别有3.6%（17/470）和1.1%（5/467）登记参加试验，危险度差异为2.5%（95%CI 0.6-4.5）。干预组0%（0/ 470）和对照组0.2%（1/467）在线注册成功，风险差-0.2（95% CI -0.6-0.2）;试验2：4.5%（11/246）的干预组和0.4%（1/245）的对照组被随机分配到Txt 2stop试验，风险差异4.0%（95%CI 1.4-6.7）;试验3：干预组3.5%（14/405）和对照组0%（0/406）被随机分配到Txt 2stop试验中，风险差异3.5（95%CI 1.7-5.2）。分配参与者ID在试验2和3是systematic.Conclusion发送短信有关的在线注册设施增加注册Txt 2stop，但并没有增加在线注册。发送（原文如此）5名参与者的时间补偿和发送包含现有参与者报价的短信增加了Txt 2stop试验的随机化。临床试验2010; 7：265-273。http://ctj.sagepub.com.
Background Recruitment is a major challenge for trials but there is little evidence regarding interventions to increase trial recruitment. We report three controlled trials of interventions to increase recruitment to the Txt2stop trial.Purpose To evaluate: Trial 1. The impact on registrations of a text message regarding an online registration facility; Trial 2. The impact on randomizations of sending (sic)5 with a covering letter to those eligible to join the trial; Trial 3. The impact on randomizations of text messages containing quotes from existing participants.Methods Single blind controlled trials with allocation concealment. Interventions: Trial 1: A text message regarding our new online registration facility; Trial 2: A letter with (sic)5 enclosed; Trial 3: A series of four text messages containing quotes from participants. The control group in each trial received standard Txt2stop procedures.Results Trial 1: 3.6% (17/470) of the intervention group and 1.1% (5/467) of the control group registered for the trial, risk difference 2.5% (95% CI 0.6-4.5). 0% (0/ 470) of the intervention group and 0.2% (1/467) of the control group registered successfully online, risk difference -0.2 (95% CI -0.6-0.2); Trial 2: 4.5% (11/246) of the intervention group and 0.4% (1/245) of the control group were randomized into the Txt2stop trial, risk difference 4.0% (95% CI 1.4-6.7); Trial 3: 3.5% (14/405) of the intervention group and 0% (0/406) of the control group were randomized into the Txt2stop trial, risk difference 3.5 (95% CI 1.7-5.2).Limitations There were no baseline data available for trial 1. Allocation of participant IDs in trials 2 and 3 were systematic.Conclusion Sending a text message about an online registration facility increased registrations to Txt2stop, but did not increase online registrations. Sending a (sic)5 reimbursement for participants' time and sending text messages containing quotes from existing participants increased randomizations into the Txt2stop trial. Clinical Trials 2010; 7: 265-273. http://ctj.sagepub.com.