Rotational symmetry of the C ring and a mechanism for the flagellar rotary motor.
Rotational symmetry of the C ring and a mechanism for the flagellar rotary motor.
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DOI：
10.1073/pnas.96.18.10134
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发表时间：
1999-08
影响因子：
11.1
通讯作者：
Dennis R. Thomas;David G.A. Morgan;D. DeRosier
中科院分区：
文献类型：
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作者：
Dennis R. Thomas;David G.A. Morgan;D. DeRosier
FliG、FliM和FliN是扭矩产生的关键蛋白，位于两个环中。第一个蛋白质位于M环，最后两个蛋白质位于C环。C环和M环的旋转对称性已被确定为约34（本文）和26（以前的工作），分别。这里提出的机制取决于环之间的对称性不匹配：C环延伸34个杠杆，其中26个可以结合到M环上的26个等价位点。剩余的8个杠杆与质子-孔复合物（螺柱）结合，形成8个扭矩发生器。运动的结果是螺柱结合杠杆与M环结合杠杆的交换。该模型预测，M环和C环都以相同的方向旋转，但速度不同。
FliG, FliM, and FliN, key proteins for torque generation, are located in two rings. The first protein is in the M ring and the last two are in the C ring. The rotational symmetries of the C and M rings have been determined to be about 34 (this paper) and 26 (previous work), respectively. The mechanism proposed here depends on the symmetry mismatch between the rings: the C ring extends 34 levers, of which 26 can bind to the 26 equivalent sites on the M ring. The remaining 8 levers bind to proton-pore complexes (studs) to form 8 torque generators. Movement results from the swapping of stud-bound levers with M ring-bound levers. The model predicts that both the M and C rings rotate in the same direction but at different speeds.